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  Hindgut defects and transformation of the gastro‐intestinal tract in Tcf4−/−/Tcf1−/− embryos

Gregorieff, A., Grosschedl, R., & Clevers, H. (2004). Hindgut defects and transformation of the gastro‐intestinal tract in Tcf4−/−/Tcf1−/− embryos. EMBO Journal, 23, 1825-1833. doi:10.1038/sj.emboj.7600191.

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Greogrieff 2004_EMBO J.pdf (Publisher version), 386KB
 
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Gregorieff, Alex1, Author
Grosschedl, Rudolf2, Author              
Clevers, Hans1, Author
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1External Organizations, ou_persistent22              
2Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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 Abstract: Wnt signalling plays a critical role in both initiating and patterning of the anterior–posterior axis during development. Wnts exert their biological effects, in part, by activating specific target genes through members of the TCF/LEF family of transcription factors. To gain new insight into the role of T‐cell factors (or Tcf's) during development, we analysed Tcf4 and Tcf1 compound null embryos. These mutants showed severe caudal truncations, as well as duplications of the neural tube. Unlike other mutations affecting Wnt signalling, paraxial mesoderm formation was not impaired and early caudal markers, such as T, were unaffected. Analysis of endodermal markers uncovered early and specific defects in hindgut expansion, and later an anterior transformation of the gastro‐intestinal tract. Our results reveal a novel role for Wnt signalling in early gut morphogenesis and suggest that specific Wnt‐driven patterning events are determined by the unique tissue distribution of Tcf/Lef family members.

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Language(s): eng - English
 Dates: 2004-04
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/sj.emboj.7600191
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Title: EMBO Journal
  Other : EMBO J.
Source Genre: Journal
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Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 23 Sequence Number: - Start / End Page: 1825 - 1833 Identifier: ISSN: 0261-4189
CoNE: https://pure.mpg.de/cone/journals/resource/954925497061