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  A human cell atlas of fetal gene expression

Cao, J., O’Day, D. R., Pliner, H. A., Kingsley, P. D., Deng, M., Daza, R. M., et al. (2020). A human cell atlas of fetal gene expression. Science, 370(6518): eaba7721. doi:10.1126/science.aba7721.

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© 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science.
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 Creators:
Cao, Junyue, Author
O’Day, Diana R. , Author
Pliner, Hannah A. , Author
Kingsley, Paul D., Author
Deng, Mei, Author
Daza, Riza M. , Author
Zager, Michael A. , Author
Aldinger, Kimberly A. , Author
Blecher-Gonen, Ronnie , Author
Zhang, Fan, Author
Spielmann, Malte1, Author              
Palis, James , Author
Doherty, Dan, Author
Steemers, Frank J. , Author
Glass, Ian A., Author
Trapnell, Cole, Author
Shendure, Jay, Author
Affiliations:
1Human Molecular Genomics (Malte Spielmann), Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_3014183              

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 Abstract: The gene expression program underlying the specification of human cell types is of fundamental interest. We generated human cell atlases of gene expression and chromatin accessibility in fetal tissues. For gene expression, we applied three-level combinatorial indexing to >110 samples representing 15 organs, ultimately profiling ~4 million single cells. We leveraged the literature and other atlases to identify and annotate hundreds of cell types and subtypes, both within and across tissues. Our analyses focused on organ-specific specializations of broadly distributed cell types (such as blood, endothelial, and epithelial), sites of fetal erythropoiesis (which notably included the adrenal gland), and integration with mouse developmental atlases (such as conserved specification of blood cells). These data represent a rich resource for the exploration of in vivo human gene expression in diverse tissues and cell types.

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Language(s): eng - English
 Dates: 2020-09-102020-11-132020-11-13
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1126/science.aba7721
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Title: Science
  Abbreviation : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 370 (6518) Sequence Number: eaba7721 Start / End Page: - Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1