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  Heart failure is independently associated with white matter lesions: Insights from the population-based LIFE-Adult Study

Stegmann, T., Chu, M. L., Witte, A. V., Villringer, A., Kumral, D., Riedel-Heller, S. G., et al. (2020). Heart failure is independently associated with white matter lesions: Insights from the population-based LIFE-Adult Study. ESC Heart Failure. doi:10.1002/ehf2.13166.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-AF94-D Version Permalink: http://hdl.handle.net/21.11116/0000-0007-AF97-A
Genre: Journal Article

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 Creators:
Stegmann, Tina1, Author
Chu, Mai L.2, Author
Witte, A. Veronica3, Author              
Villringer, Arno3, Author              
Kumral, Deniz3, Author              
Riedel-Heller, Steffi G.4, Author
Roehr, Susanne4, Author
Hagendorff, Andreas1, Author
Laufs, Ulrich1, Author
Löffler, Markus2, 5, Author
Wachter, Rolf1, 6, 7, Author
Zeynalova, Samira1, 5, Author
Affiliations:
1Clinic and Policlinic for Cardiology, University Hospital Leipzig, Germany, ou_persistent22              
2Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
4Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
5Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
6Clinic for Cardiology and Pneumology, University Medical Center, Göttingen, Germany, ou_persistent22              
7German Centre for Cardiovascular Research, Göttingen, Germany, ou_persistent22              

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Free keywords: Cognitive impairment; Heart failure; Magnetic resonance imaging; Population-based study; White matter lesions
 Abstract: Aims: White matter lesions (WML) are common structural alterations in the white matter of the brain and their prevalence increases with age. They are associated with cerebral ischaemia and cognitive dysfunction. Patients with heart failure (HF) are at risk for cognitive decline. We hypothesized that the presence and duration of HF are associated with WML. Methods and results: The LIFE-Adult Study is a population-based study of 10 000 residents of Leipzig, Germany. WML were quantitated in 2490 participants who additionally underwent cerebral MRI using the Fazekas score. Mean age was 64 years, and 46% were female; 2156 (86.6%) subjects had Fazekas score of 0-1, and 334 (13.4%) had Fazekas score of 2-3. Thirty participants had a medical history of HF, 1019 had hypertension, and 51 had a history of stroke. Median left ventricular ejection fraction of the participants with HF was 57% (interquartile ranges 54-62). Age, troponin T, NT-proBNP, body mass index, history of acute myocardial infarction, stroke, HF, and diabetes were positively associated with WML in univariate analysis. On multivariate analysis, age, hypertension, stroke, and HF were independently associated with WML. The odd's ratio for the association of WML (Fazekas 2-3) with HF was 2.8 (95% CI 1.2-6.5; P = 0.019). WML increased with longer duration of HF (P = 0.036 for trend). Conclusions: In addition to age, hypertension, and stroke, the prevalence and duration of HF are independently associated with WML. This observation sets the stage to investigate the prognostic value of WML in HF and the impact of HF therapies on WML.

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Language(s): eng - English
 Dates: 2020-12-15
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/ehf2.13166
Other: online ahead of print
PMID: 33321550
 Degree: -

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Title: ESC Heart Failure
Source Genre: Journal
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Publ. Info: Chichester : Wiley
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 2055-5822
CoNE: https://pure.mpg.de/cone/journals/resource/2055-5822