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  Species differences between rat and rabbit renal Na+/H+ exchangers

Friedrich, T., Sablotni, J., & Burckhardt, G. (1987). Species differences between rat and rabbit renal Na+/H+ exchangers. Biochemical and Biophysical Research Communications, 144(2), 869-875. doi:10.1016/s0006-291x(87)80045-1.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-D2D3-D Version Permalink: https://hdl.handle.net/21.11116/0000-0007-D2D4-C
Genre: Journal Article

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 Creators:
Friedrich, Thomas1, Author           
Sablotni, Jutta1, Author           
Burckhardt, Gerhard1, Author           
Affiliations:
1Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068297              

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 Abstract: Amiloride, 5-ethylisopropylamiloride (EIPA), and 5-ethylisopropyl-6-bromo-amiloride (Br-EIPA) inhibit rabbit and rat renal Na+/H+ exchangers with comparable potency. Irreversible inhibitions by Br-EIPA after irradiation of rat and rabbit renal brush-border vesicles are also similar. In contrast, irreversible inhibition by N,N'-dicyclohexylcarbodiimide (DCCD) of the rabbit renal antiporter requires higher DCCD concentrations as compared to the rat. Rabbit renal brush-border membranes show highest [14C]DCCD incorporation at MW 80,000, 51,000 and 36,000 and lack the amiloride-protectable MW 65,000 protein previously identified as Na+/H+ exchanger in rat kidney cortex. The data indicate species differences with respect to renal Na+/H+ exchangers.

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Language(s): eng - English
 Dates: 1987-03-122005-04-221987-04-29
 Publication Status: Issued
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/s0006-291x(87)80045-1
PMID: 3034266
 Degree: -

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Title: Biochemical and Biophysical Research Communications
  Other : Biochem. Biophys. Res. Commun.
Source Genre: Journal
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Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: 144 (2) Sequence Number: - Start / End Page: 869 - 875 Identifier: ISSN: 0006-291X
CoNE: https://pure.mpg.de/cone/journals/resource/954922652205_1