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  Activatable fluorescent probes for hydrolase enzymes based on coumarin-hemicyanine hybrid fluorophores with large Stokes shifts

Fujioka, H., Uno, S.-n., Kamiya, M., Kojima, R., Johnsson, K., & Urano, Y. (2020). Activatable fluorescent probes for hydrolase enzymes based on coumarin-hemicyanine hybrid fluorophores with large Stokes shifts. Chemical Communications, 56(42), 5617-5620. doi:10.1039/d0cc00559b.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-B0FF-3 Version Permalink: https://hdl.handle.net/21.11116/0000-0007-B100-0
Genre: Journal Article

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 Creators:
Fujioka, Hiroyoshi, Author
Uno, Shin-nosuke, Author
Kamiya, Mako, Author
Kojima, Ryosuke, Author
Johnsson, Kai1, Author           
Urano, Yasuteru, Author
Affiliations:
1Chemical Biology, Max Planck Institute for Medical Research, Max Planck Society, ou_2364732              

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 Abstract: We show that the equilibrium of intramolecular spirocyclization of coumarin-hemicyanine hybrid fluorophores can be finely tuned by means of chemical modifications. We used this scaffold to develop activatable fluorescent probes with large Stokes shifts for γ-glutamyltranspeptidase and esterase.

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Language(s): eng - English
 Dates: 2020-03-042020-03-302020-03-302020-05-27
 Publication Status: Issued
 Pages: 4
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/d0cc00559b
URI: https://pubmed.ncbi.nlm.nih.gov/32297612/
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Title: Chemical Communications
  Other : Chem. Commun.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 56 (42) Sequence Number: - Start / End Page: 5617 - 5620 Identifier: ISSN: 1359-7345
CoNE: https://pure.mpg.de/cone/journals/resource/954928495413