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  Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep

Bojarskaite, L., Bjørnstad, D. M., Pettersen, K. H., Cunen, C., Hermansen, G. H., Åbjørsbråten, K. S., et al. (2020). Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep. Nature Communications, 11: 3240 (2020), pp. 1-16. doi:10.1038/s41467-020-17062-2.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-B17A-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-B318-4
Genre: Journal Article
Alternative Title : Astrocytic Ca(2+) signaling is reduced during sleep and is involved in the regulation of slow wave sleep

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 Creators:
Bojarskaite, Laura, Author
Bjørnstad, Daniel M., Author
Pettersen, Klas H., Author
Cunen, Céline, Author
Hermansen, Gudmund Horn, Author
Åbjørsbråten, Knut Sindre, Author
Chambers, Anna R., Author
Sprengel, Rolf1, Author              
Vervaeke, Koen, Author
Tang, Wannan, Author
Enger, Rune, Author
Nagelhus, Erlend A., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity, brain rhythms and behavior. We show that astrocytic Ca2+ signals exhibit distinct features across the sleep-wake cycle and are reduced during sleep compared to wakefulness. Moreover, an increase in astrocytic Ca2+ signaling precedes transitions from slow wave sleep to wakefulness, with a peak upon awakening exceeding the levels during whisking and locomotion. Finally, genetic ablation of an important astrocytic Ca2+ signaling pathway impairs slow wave sleep and results in an increased number of microarousals, abnormal brain rhythms, and an increased frequency of slow wave sleep state transitions and sleep spindles. Our findings demonstrate an essential role for astrocytic Ca2+ signaling in regulating slow wave sleep.

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Language(s): eng - English
 Dates: 2019-09-272020-06-092020-07-06
 Publication Status: Published online
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-020-17062-2
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 11 Sequence Number: 3240 (2020) Start / End Page: 1 - 16 Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723