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  Subcellular analysis of pigeon hair cells implicates vesicular trafficking in cuticulosome formation and maintenance

Nimpf, S., Malkemper, E. P., Lauwers, M., Ushakova, L., Nordmann, G., Wenninger-Weinzierl, A., et al. (2017). Subcellular analysis of pigeon hair cells implicates vesicular trafficking in cuticulosome formation and maintenance. eLife, 6: e29959. doi:10.7554/eLife.29959.

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https://elifesciences.org/articles/29959 (Publisher version)
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Nimpf, Simon1, Author
Malkemper, E. Pascal1, 2, Author           
Lauwers, Mattias1, Author
Ushakova, Lyubov1, Author
Nordmann, Gregory1, Author
Wenninger-Weinzierl, Andrea1, Author
Burkard, Thomas R.1, Author
Jacob, Sonja1, Author
Heuser, Thomas1, Author
Resch, Guenter P.1, Author
Keays, David A.1, Author
Affiliations:
1external, ou_persistent22              
2Max Planck Research Group Neurobiology of Magnetoreception, Center of Advanced European Studies and Research (caesar), Max Planck Society, ou_3169318              

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 Abstract: Hair cells are specialized sensors located in the inner ear that enable the transduction of sound, motion, and gravity into neuronal impulses. In birds some hair cells contain an iron-rich organelle, the cuticulosome, that has been implicated in the magnetic sense. Here, we exploit histological, transcriptomic, and tomographic methods to investigate the development of cuticulosomes, as well as the molecular and subcellular architecture of cuticulosome positive hair cells. We show that this organelle forms rapidly after hatching in a process that involves vesicle fusion and nucleation of ferritin nanoparticles. We further report that transcripts involved in endocytosis, extracellular exosomes, and metal ion binding are differentially expressed in cuticulosome positive hair cells. These data suggest that the cuticulosome and the associated molecular machinery regulate the concentration of iron within the labyrinth of the inner ear, which might indirectly tune a magnetic sensor that relies on electromagnetic induction.

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Language(s): eng - English
 Dates: 2017-11-15
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000425873800001
DOI: 10.7554/eLife.29959
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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 6 Sequence Number: e29959 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X