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  Novel integrative elements and genomic plasticity in ocean ecosystems

Hackl, T., Laurenceau, R., Ankenbrand, M. J., Bliem, C., Cariani, Z., Thomas, E., et al. (2020). Novel integrative elements and genomic plasticity in ocean ecosystems. bioRxiv, 1-18. doi:10.1101/2020.12.28.424599.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-B29A-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-B29B-1
Genre: Journal Article

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 Creators:
Hackl, Thomas1, Author              
Laurenceau, Raphaël, Author
Ankenbrand, Markus J., Author
Bliem, Christina, Author
Cariani, Zev, Author
Thomas, Elaina, Author
Dooley, Keven D., Author
Arellano, Aldo A., Author
Hogle, Shane L., Author
Berube, Paul, Author
Leventhal, Gabriel E., Author
Luo, Elaine, Author
Eppley, John, Author
Zayed, Ahmed A., Author
Beaulaurier, John, Author
Stepanauskas, Ramunas, Author
Sullivan, Matthew B., Author
DeLong, Edward F., Author
Biller, Steven J., Author
Chisholm, Sallie W., Author
Affiliations:
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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 Abstract: Horizontal gene transfer accelerates microbial evolution, promoting diversification and adaptation. The globally abundant marine cyanobacterium Prochlorococcus has a highly streamlined genome with frequent gene exchange reflected in its extensive pangenome. The source of its genomic variability, however, remains elusive since most cells lack the common mechanisms that enable horizontal gene transfer, including conjugation, transformation, plasmids and prophages. Examining 623 genomes, we reveal a diverse system of mobile genetic elements – cargo-carrying transposons we named tycheposons – that shape Prochlorococcus’ genomic plasticity. The excision and integration of tycheposons at seven tRNA genes drive the remodeling of larger genomic islands containing most of Prochlorococcus’ flexible genes. Most tycheposons carry genes important for niche differentiation through nutrient acquisition; others appear similar to phage parasites. Tycheposons are highly enriched in extracellular vesicles and phage particles in ocean samples, suggesting efficient routes for their dispersal, transmission and propagation. Supported by evidence for similar elements in other marine microbes, our work underpins the role of vesicle- and virus-mediated transfer of mobile genetic elements in the diversification and adaptation of microbes in dilute aquatic environments – adding a significant piece to the puzzle of what governs microbial evolution in the planet’s largest habitat.

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Language(s): eng - English
 Dates: 2020-12-28
 Publication Status: Published online
 Pages: 18
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1101/2020.12.28.424599
 Degree: -

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Title: bioRxiv
Source Genre: Collected Edition
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 1 - 18 Identifier: -