English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Levodopa‐induced dyskinesia are mediated by cortical gamma oscillations in experimental Parkinsonism

Güttler, C., Altschüler, J., Tanev, K., Böckmann, S., Haumesser, J. K., Nikulin, V. V., et al. (2020). Levodopa‐induced dyskinesia are mediated by cortical gamma oscillations in experimental Parkinsonism. Movement Disorders. doi:10.1002/mds.28403.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Guettler_2020.pdf (Publisher version), 4MB
Name:
Guettler_2020.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Güttler, Christopher1, Author
Altschüler, Jennifer1, Author
Tanev, Kaloyan1, Author
Böckmann, Saskia1, Author
Haumesser, Jens Kersten1, Author
Nikulin, Vadim V.2, Author              
Kühn, Andrea A.1, 3, 4, Author
Riesen, Christoph1, 3, 4, 5, Author
Affiliations:
1Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Berlin Institute of Health (BIH), Germany, ou_persistent22              
4German Center for Neurodegenerative Diseases, Bonn, Germany, ou_persistent22              
5Department of Cognitive Neurology, University Medical Center, Göttingen, Germany, ou_persistent22              

Content

show
hide
Free keywords: 6-OHDA; Dyskinesia; Gamma oscillations
 Abstract: Background Levodopa is the most efficacious drug in the symptomatic therapy of motor symptoms in Parkinson's disease (PD); however, long‐term treatment is often complicated by troublesome levodopa‐induced dyskinesia (LID). Recent evidence suggests that LID might be related to increased cortical gamma oscillations. Objective The objective of this study was to test the hypothesis that cortical high‐gamma network activity relates to LID in the 6‐hydroxydopamine model and to identify new biomarkers for adaptive deep brain stimulation (DBS) therapy in PD. Methods We recorded and analyzed primary motor cortex (M1) electrocorticogram data and motor behavior in freely moving 6‐OHDA lesioned rats before and during a daily treatment with levodopa for 3 weeks. The results were correlated with the abnormal involuntary movement score (AIMS) and used for generalized linear modeling (GLM). Results Levodopa reverted motor impairment, suppressed beta activity, and, with repeated administration, led to a progressive enhancement of LID. Concurrently, we observed a highly significant stepwise amplitude increase in finely tuned gamma (FTG) activity and gamma centroid frequency. Whereas AIMS and FTG reached their maximum after the 4th injection and remained on a stable plateau thereafter, the centroid frequency of the FTG power continued to increase thereafter. Among the analyzed gamma activity parameters, the fraction of longest gamma bursts showed the strongest correlation with AIMS. Using a GLM, it was possible to accurately predict AIMS from cortical recordings. Conclusions FTG activity is tightly linked to LID and should be studied as a biomarker for adaptive DBS.

Details

show
hide
Language(s): eng - English
 Dates: 2020-10-082020-07-212020-10-302020-11-28
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/mds.28403
Other: online ahead of print
PMID: 33247603
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : GE 2629/1‐1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft

Source 1

show
hide
Title: Movement Disorders
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : John Wiley & Sons
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0885-3185
CoNE: https://pure.mpg.de/cone/journals/resource/954925551353