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  Amplification and direct sequencing of a cDNA encoding human cytosolic 3-hydroxy-3- methylglutaryl-coenzyme A synthase

Russ, A. P., Ruzicka, V., Maerz, W., Appelhans, H., & Groß, W. (1992). Amplification and direct sequencing of a cDNA encoding human cytosolic 3-hydroxy-3- methylglutaryl-coenzyme A synthase. Biochimica et Biophysica Acta-Gene Structure and Expression, 1132(3), 329-331. doi:10.1016/0167-4781(92)90172-v.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-E8C9-1 Version Permalink: https://hdl.handle.net/21.11116/0000-0007-E8CA-0
Genre: Journal Article

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 Creators:
Russ, Andreas P.1, Author
Ruzicka, Viktor1, Author
Maerz, Winfried1, Author
Appelhans, Heribert2, Author           
Groß, Werner1, Author
Affiliations:
1Gustav Embden-Zentrum der biologischen Chemie, Johann Wolfgang Goethe-Universität, Frankfurt, Germany, ou_persistent22              
2Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society, ou_3264817              

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Free keywords: 3-Hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase cDNA; Cholesterol biosynthesis; Isoprenoid biosynthesis; (Human)
 Abstract: Cytosolic 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase (E.C. 4.1.3.5) is a highly regulated enzyme involved in isoprenoid biosynthesis and therefore a potential target for cholesterol-lowering drugs. Up to now, primary structure data have only been available for chicken, rat and hamster HMG-CoA synthase. Using in vitro amplification and direct sequencing, we have determined the nucleotide sequence of the coding region of the human cytosolic 3-hydroxy-3-methylglutaryl CoA synthase cDNA.

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Language(s): eng - English
 Dates: 1992-08-052002-12-171992-10-20
 Publication Status: Issued
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/0167-4781(92)90172-v
PMID: 1358203
 Degree: -

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Title: Biochimica et Biophysica Acta-Gene Structure and Expression
  Other : Biochim. Biophys. Acta-Gene Struct. Expression
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Elsevier
Pages: - Volume / Issue: 1132 (3) Sequence Number: - Start / End Page: 329 - 331 Identifier: ISSN: 0167-4781
CoNE: https://pure.mpg.de/cone/journals/resource/954926938702_1