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  Factor graph analysis of live cell–imaging data reveals mechanisms of cell fate decisions

Niederberger, T., Failmezger, H., Uskat, D., Poron, D., Glauche, I., Scherf, N., et al. (2015). Factor graph analysis of live cell–imaging data reveals mechanisms of cell fate decisions. Bioinformatics, 31(11), 1816-1823. doi:10.1093/bioinformatics/btv040.

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Genre: Journal Article

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 Creators:
Niederberger, Theresa1, Author
Failmezger, Henrik1, Author
Uskat, Diana1, Author
Poron, Don1, Author
Glauche, Ingmar1, Author
Scherf, Nico1, Author              
Roeder, Ingo1, Author
Schroeder, Timm1, Author
Tresch, Achim1, Author
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1External Organizations, ou_persistent22              

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 Abstract: Motivation : Cell fate decisions have a strong stochastic component. The identification of the underlying mechanisms therefore requires a rigorous statistical analysis of large ensembles of single cells that were tracked and phenotyped over time. Results : We introduce a probabilistic framework for testing elementary hypotheses on dynamic cell behavior using time-lapse cell-imaging data. Factor graphs, probabilistic graphical models, are used to properly account for cell lineage and cell phenotype information. Our model is applied to time-lapse movies of murine granulocyte-macrophage progenitor (GMP) cells. It decides between competing hypotheses on the mechanisms of their differentiation. Our results theoretically substantiate previous experimental observations that lineage instruction, not selection is the cause for the differentiation of GMP cells into mature monocytes or neutrophil granulocytes.

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Language(s): eng - English
 Dates: 2014-12-312014-10-202015-01-192015-01-312015-06-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/bioinformatics/btv040
PMID: 25638814
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Title: Bioinformatics
Source Genre: Journal
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Publ. Info: Oxford : Oxford University Press
Pages: - Volume / Issue: 31 (11) Sequence Number: - Start / End Page: 1816 - 1823 Identifier: ISSN: 1367-4803
CoNE: https://pure.mpg.de/cone/journals/resource/954926969991