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  Epigenetic Regulators as the Gatekeepers of Hematopoiesis

Pessoa Rodrigues, C., Shvedunova, M., & Akhtar, A. (2021). Epigenetic Regulators as the Gatekeepers of Hematopoiesis. Trends in Genetics, 37, 125-142. doi:10.1016/j.tig.2020.09.015.

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Pessoa et al. 2021.pdf (Publisher version), 3MB
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Pessoa et al. 2021.pdf
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2020
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 Creators:
Pessoa Rodrigues, Cecilia1, Author
Shvedunova, Maria1, Author
Akhtar, Asifa1, Author              
Affiliations:
1Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243643              

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Free keywords: chromatin dynamics; hematopoiesis; cell fate determination; epigenetics
 Abstract: Hematopoiesis is the process by which both fetal and adult organisms derive the full repertoire of blood cells from a single multipotent progenitor cell type, the hematopoietic stem cells (HSCs). Correct enactment of this process relies on a synergistic interplay between genetically encoded differentiation programs and a host of cell-intrinsic and cell-extrinsic factors. These include the influence of the HSC niche microenvironment, action of specific transcription factors, and alterations in intracellular metabolic state. The consolidation of these inputs with the genetically encoded program into a coherent differentiation program for each lineage is thought to rely on epigenetic modifiers. Recent work has delineated the precise contributions of different classes of epigenetic modifiers to HSC self-renewal as well as lineage specification and differentiation into various cell types. Here, we bring together what is currently known about chromatin status and the development of cells in the hematopoietic system under normal and abnormal conditions.

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Language(s): eng - English
 Dates: 2020-10-212021-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.tig.2020.09.015
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Title: Trends in Genetics
  Other : Trends Genet.
Source Genre: Journal
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Publ. Info: Elsevier Current Trends
Pages: - Volume / Issue: 37 Sequence Number: - Start / End Page: 125 - 142 Identifier: ISSN: 0168-9525
CoNE: https://pure.mpg.de/cone/journals/resource/954925485719