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  Molecular hydrogen (H2) as a potential treatment for acute and chronic fatigue

Lucas, K., Rosch, M., & Langguth, P. (2020). Molecular hydrogen (H2) as a potential treatment for acute and chronic fatigue. Archiv der Pharmazie, e2000378. doi:10.1002/ardp.202000378.

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Genre: Journal Article

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 Creators:
Lucas, Kurt1, Author              
Rosch, Moritz1, Author              
Langguth, Peter2, Author
Affiliations:
1Multiphase Chemistry, Max Planck Institute for Chemistry, Max Planck Society, ou_1826290              
2external, ou_persistent22              

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 Abstract: Many diseases as well as acute conditions can lead to fatigue, which can be either temporary or chronic in nature. Acute fatigue develops frequently after physical exercise or after alcohol hangover, whereas microbial infections such as influenza or COVID‐19 and chronic diseases like Parkinson's disease or multiple sclerosis are often associated with chronic fatigue. Oxidative stress and a resulting disturbance of mitochondrial function are likely to be common denominators for many forms of fatigue, and antioxidant treatments have been shown to be effective in alleviating the symptoms of fatigue. In this study, we review the role of reactive oxygen and nitrogen species in fatigue and the antioxidant effects of the intake of molecular hydrogen. We propose that molecular hydrogen is well suited for the treatment of temporary and chronic forms of oxidative stress‐associated fatigue.

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Language(s): eng - English
 Dates: 2020-12-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000602966700001
DOI: 10.1002/ardp.202000378
 Degree: -

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Title: Archiv der Pharmazie
  Other : Arch Pharm
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Weinheim, Germany : VCH Verlagsgesellschaft mbH, [etc.]
Pages: - Volume / Issue: - Sequence Number: e2000378 Start / End Page: - Identifier: ISSN: 0365-6233
CoNE: https://pure.mpg.de/cone/journals/resource/954927666192