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  Pulling the brakes on fast and furious multiple drug-resistant (MDR) bacteria

Khan, A. A., Manzoor, K. N., Sultan, A., Saeed, M., Rafique, M., Noushad, S., et al. (2021). Pulling the brakes on fast and furious multiple drug-resistant (MDR) bacteria. International Journal of Molecular Sciences, 22(2): 859. doi:10.3390/ijms22020859.

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 Urheber:
Khan, Abid Ali, Autor
Manzoor, Khanzadi Nazneen, Autor
Sultan, Aamir, Autor
Saeed, Maria, Autor
Rafique, Mahrukh, Autor
Noushad, Sameen, Autor
Talib, Ayesha1, Autor           
Rentschler, Simone, Autor
Deigner, Hans-Peter, Autor
Affiliations:
1Kerstin Blank, Mechano(bio)chemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2301698              

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Schlagwörter: multidrug resistance; nanoantibiotics; nanoparticles; combination therapy; bacteriophages
 Zusammenfassung: Life-threatening bacterial infections have been managed by antibiotics for years and have significantly improved the wellbeing and lifetime of humans. However, bacteria have always been one step ahead by inactivating the antimicrobial agent chemically or by producing certain enzymes. The alarming universal occurrence of multidrug-resistant (MDR) bacteria has compelled researchers to find alternative treatments for MDR infections. This is a menace where conventional chemotherapies are no longer promising, but several novel approaches could help. Our current review article discusses the novel approaches that can combat MDR bacteria: starting off with potential nanoparticles (NPs) that efficiently interact with microorganisms causing fatal changes in the morphology and structure of these cells; nanophotothermal therapy using inorganic NPs like AuNPs to destroy pathogenic bacterial cells; bacteriophage therapy against which bacteria develop less resistance; combination drugs that act on dissimilar targets in distinctive pathways; probiotics therapy by the secretion of antibacterial chemicals; blockage of quorum sensing signals stopping bacterial colonization, and vaccination against resistant bacterial strains along with virulence factors. All these techniques show us a promising future in the fight against MDR bacteria, which remains the greatest challenge in public health care.

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Sprache(n): eng - English
 Datum: 2021-01-162021
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Identifikatoren: DOI: 10.3390/ijms22020859
BibTex Citekey: ijms22020859
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Titel: International Journal of Molecular Sciences
  Kurztitel : Int. J. Mol. Sci.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Basel, Switzerland : MDPI AG
Seiten: - Band / Heft: 22 (2) Artikelnummer: 859 Start- / Endseite: - Identifikator: ISSN: 1422-0067