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  The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics

Bautista-Sánchez, D., Arriaga-Canon, C., Pedroza-Torres, A., La Rosa-Valázquez, I. A. D., González-Barrios, R., Contreras-Espinosa, L., et al. (2020). The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics. Molecular Therapy, 20, 409-419. doi:10.1016/j.omtn.2020.03.003.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0007-DF95-6 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0008-7F7F-D
Genre: Zeitschriftenartikel

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Bautista et al. 2020.pdf (Verlagsversion), 812KB
 
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2020
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118281/pdf/main.pdf (Verlagsversion)
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 Urheber:
Bautista-Sánchez, Diana1, Autor
Arriaga-Canon, Cristian1, Autor
Pedroza-Torres, Abraham1, Autor
La Rosa-Valázquez, Inti Alberto De2, Autor
González-Barrios, Rodrigo1, Autor
Contreras-Espinosa, Laura1, Autor
Montiel-Manríquez, Rogelio1, Autor
Castro-Hernández, Clementina1, Autor
Fragoso-Ontiveros, Verónica1, Autor
Álvarez-Gómez, Rosa María1, Autor
Herrera, Luis A.1, Autor
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              

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 Zusammenfassung: MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene expression via base-pairing complementarity. Their role in cancer can be related to tumor suppression or oncogenic function. Moreover, they have been linked to processes recognized as hallmarks of cancer, such as apoptosis, invasion, metastasis, and proliferation. Particularly, one of the first oncomiRs found upregulated in a variety of cancers, such as gliomas, breast cancer, and colorectal cancer, was microRNA-21 (miR-21). Some of its target genes associated with cancer are PTEN (phosphatase and tensin homolog), PDCD4 (programmed cell death protein 4), RECK (reversion-inducing cysteine-rich protein with Kazal motifs), and STAT3 (signal transducer activator of transcription 3). As a result, miR-21 has been proposed as a plausible diagnostic and prognostic biomarker, as well as a therapeutic target for several types of cancer. Currently, research and clinical trials to inhibit miR-21 through anti-miR-21 oligonucleotides and ADM-21 are being conducted. As all of the evidence suggests, miR-21 is involved in carcinogenic processes; therefore, inhibiting it could have effects on more than one type of cancer. However, whether miR-21 can be used as a tissue-specific biomarker should be analyzed with caution. Consequently, the purpose of this review is to outline the available information and recent advances regarding miR-21 as a potential biomarker in the clinical setting and as a therapeutic target in cancer to highlight its importance in the era of precision medicine.

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Sprache(n): eng - English
 Datum: 2020-06
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.omtn.2020.03.003
 Art des Abschluß: -

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Titel: Molecular Therapy
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: San Diego, CA : No longer published by Elsevier
Seiten: - Band / Heft: 20 Artikelnummer: - Start- / Endseite: 409 - 419 Identifikator: ISSN: 1525-0016
CoNE: https://pure.mpg.de/cone/journals/resource/961066780010