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  The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics

Bautista-Sánchez, D., Arriaga-Canon, C., Pedroza-Torres, A., La Rosa-Valázquez, I. A. D., González-Barrios, R., Contreras-Espinosa, L., et al. (2020). The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics. Molecular Therapy, 20, 409-419. doi:10.1016/j.omtn.2020.03.003.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-DF95-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0007-DF96-5
Genre: Journal Article

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Bautista et al. 2020.pdf (Publisher version), 812KB
 
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2020
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118281/pdf/main.pdf (Publisher version)
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 Creators:
Bautista-Sánchez, Diana1, Author
Arriaga-Canon, Cristian1, Author
Pedroza-Torres, Abraham1, Author
La Rosa-Valázquez, Inti Alberto De2, Author
González-Barrios, Rodrigo1, Author
Contreras-Espinosa, Laura1, Author
Montiel-Manríquez, Rogelio1, Author
Castro-Hernández, Clementina1, Author
Fragoso-Ontiveros, Verónica1, Author
Álvarez-Gómez, Rosa María1, Author
Herrera, Luis A.1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              

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 Abstract: MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene expression via base-pairing complementarity. Their role in cancer can be related to tumor suppression or oncogenic function. Moreover, they have been linked to processes recognized as hallmarks of cancer, such as apoptosis, invasion, metastasis, and proliferation. Particularly, one of the first oncomiRs found upregulated in a variety of cancers, such as gliomas, breast cancer, and colorectal cancer, was microRNA-21 (miR-21). Some of its target genes associated with cancer are PTEN (phosphatase and tensin homolog), PDCD4 (programmed cell death protein 4), RECK (reversion-inducing cysteine-rich protein with Kazal motifs), and STAT3 (signal transducer activator of transcription 3). As a result, miR-21 has been proposed as a plausible diagnostic and prognostic biomarker, as well as a therapeutic target for several types of cancer. Currently, research and clinical trials to inhibit miR-21 through anti-miR-21 oligonucleotides and ADM-21 are being conducted. As all of the evidence suggests, miR-21 is involved in carcinogenic processes; therefore, inhibiting it could have effects on more than one type of cancer. However, whether miR-21 can be used as a tissue-specific biomarker should be analyzed with caution. Consequently, the purpose of this review is to outline the available information and recent advances regarding miR-21 as a potential biomarker in the clinical setting and as a therapeutic target in cancer to highlight its importance in the era of precision medicine.

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Language(s): eng - English
 Dates: 2020-06
 Publication Status: Issued
 Pages: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.omtn.2020.03.003
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Title: Molecular Therapy
Source Genre: Journal
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Publ. Info: San Diego, CA : No longer published by Elsevier
Pages: - Volume / Issue: 20 Sequence Number: - Start / End Page: 409 - 419 Identifier: ISSN: 1525-0016
CoNE: https://pure.mpg.de/cone/journals/resource/961066780010