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  Honey bee suppresses the parasitic mite Vitellogenin by antimicrobial peptide

Wu, Y., Liu, Q., Weiss, B., Kaltenpoth, M., & Kadowaki, T. (2020). Honey bee suppresses the parasitic mite Vitellogenin by antimicrobial peptide. Frontiers in Microbiology, 11: 1037. doi:10.3389/fmicb.2020.01037.

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https://doi.org/10.3389/fmicb.2020.01037 (Publisher version)
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 Creators:
Wu, Yunfei, Author
Liu, Qiushi, Author
Weiss, Benjamin1, Author              
Kaltenpoth, Martin1, Author              
Kadowaki, Tatsuhiko, Author
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1External Organizations, ou_persistent22              

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Free keywords: DEFORMED-WING VIRUS; PICORNA-LIKE VIRUS; APIS-MELLIFERA; VARROA-DESTRUCTOR; GENE-EXPRESSION; SEQUENCE; ECTOPARASITE; PARTICLES; INFECTION; HOSTMicrobiology; host-parasite; pathogen interaction; vector-pathogen interaction; honey bee; parasitic mite; deformed wing virus; antimicrobial peptide; Vitellogenin;
 Abstract: The negative effects of honey bee parasitic mites and deformed wing virus (DWV) on honey bee and colony health have been well characterized. However, the relationship between DWV and mites, particularly viral replication inside the mites, remains unclear. Furthermore, the physiological outcomes of honey bee immune responses stimulated by DWV and the mite to the host (honey bee) and perhaps the pathogen/parasite (DWV/mite) are not yet understood. To answer these questions, we studied the tripartite interactions between the honey bee, Tropilaelaps mercedesae, and DWV as the model. T. mercedesae functioned as a vector for DWV without supporting active viral replication. Thus, DWV negligibly affected mite fitness. Mite infestation induced mRNA expression of antimicrobial peptides (AMPs), Defensin-1 and Hymenoptaecin, which correlated with DWV copy number in honey bee pupae and mite feeding, respectively. Feeding T. mercedesae with fruit fly S2 cells heterologously expressing honey bee Hymenoptaecin significantly downregulated mite Vitellogenin expression, indicating that the honey bee AMP manipulates mite reproduction upon feeding on bee. Our results provide insights into the mechanism of DWV transmission by the honey bee parasitic mite to the host, and the novel role of AMP in defending against mite infestation.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published online
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fmicb.2020.01037
Other: KAL109
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Title: Frontiers in Microbiology
  Abbreviation : Front. Microbiol.
Source Genre: Journal
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Publ. Info: Lausanne : Frontiers Media
Pages: - Volume / Issue: 11 Sequence Number: 1037 Start / End Page: - Identifier: ISSN: 1664-302X
CoNE: https://pure.mpg.de/cone/journals/resource/1664-302X