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  Nephronophthisis gene products display RNA-binding properties and are recruited to stress granules

Estrada Mallarino, L., Engel, C., Ilik, I. A., Maticzka, D., Heyl, F., Müller, B., et al. (2020). Nephronophthisis gene products display RNA-binding properties and are recruited to stress granules. Scientific Reports, 10, 1-14. doi:org/10.1038/s41598-020-72905-8.

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Mallarino et al. 2020.pdf (Publisher version), 8MB
 
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 Creators:
Estrada Mallarino, Luisa1, Author
Engel, Christina1, Author
Ilik, Ibrahim Avsar2, Author              
Maticzka, Daniel1, Author
Heyl, Florian1, Author
Müller, Barbara1, Author
Yakulov, Toma A.1, Author
Dengjel, Jörn1, Author
Backofen, Rolf1, Author
Akhtar, Asifa2, Author              
Walz, Gerd1, Author
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1External Organizations, ou_persistent22              
2Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243643              

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 Abstract: Mutations of cilia-associated molecules cause multiple developmental defects that are collectively termed ciliopathies. However, several ciliary proteins, involved in gating access to the cilium, also assume localizations at other cellular sites including the nucleus, where they participate in DNA damage responses to maintain tissue integrity. Molecular insight into how these molecules execute such diverse functions remains limited. A mass spectrometry screen for ANKS6-interacting proteins suggested an involvement of ANKS6 in RNA processing and/or binding. Comparing the RNA-binding properties of the known RNA-binding protein BICC1 with the three ankyrin-repeat proteins ANKS3, ANKS6 (NPHP16) and INVERSIN (NPHP2) confirmed that certain nephronophthisis (NPH) family members can interact with RNA molecules. We also observed that BICC1 and INVERSIN associate with stress granules in response to translational inhibition. Furthermore, BICC1 recruits ANKS3 and ANKS6 into TIA-1-positive stress granules after exposure to hippuristanol. Our findings uncover a novel function of NPH family members, and provide further evidence that NPH family members together with BICC1 are involved in stress responses to maintain tissue and organ integrity.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: org/10.1038/s41598-020-72905-8
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 10 Sequence Number: - Start / End Page: 1 - 14 Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322