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  Osteopontin Expression Identifies a Subsetof Recruited Macrophages Distinctfrom Kupffer Cells in the Fatty Liver

Remmerie, A., Martens, L., ́Thone, T., Castoldi, A., Seurinck, R., Pavie, B., et al. (2020). Osteopontin Expression Identifies a Subsetof Recruited Macrophages Distinctfrom Kupffer Cells in the Fatty Liver. Immunity, 53, 641-657. doi:org/10.1016/j.immuni.2020.08.004.

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Remmerie et al. 2020.pdf (Publisher version), 10MB
 
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2020
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 Creators:
Remmerie, Anneleen1, Author
Martens, Liesbet1, Author
́Thone, Tinne 1, Author
Castoldi, Angela2, Author
Seurinck, Ruth1, Author
Pavie, Benjamin1, Author
Roels, Joris1, Author
Vanneste, Bavo1, Author
Prijck, Sofie De1, Author
Vanhockerhout, Mathias1, Author
Latib, Mushida Binte Abdul1, Author
Devisscher, Lindsey1, Author
Hoorens, Anne1, Author
Bonnardel, Johnny1, Author
Vandamme, Niels1, Author
Kremer, Anna1, Author
Borghgraef, Peter1, Author
Vlierberghe, Hans Van1, Author
Lippens, Saskia1, Author
Pearce, Edward J.2, Author           
Saeys, Yvan1, AuthorScott, and Charlotte L.1, Author more..
Affiliations:
1External Organizations, ou_persistent22              
2Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243648              

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 Abstract: Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of disease states ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic macrophages, specifically Kupffer cells (KCs), are suggested to play important roles in the pathogenesis of MAFLD through their activation, although the exact roles played by these cells remain unclear. Here, we demonstrated that KCs were reduced in MAFLD being replaced by macrophages originating from the bone marrow. Recruited macrophages existed in two subsets with distinct activation states, either closely resembling homeostatic KCs or lipid-associated macrophages (LAMs) from obese adipose tissue. Hepatic LAMs expressed Osteopontin, a biomarker for patients with NASH, linked with the development of fibrosis. Fitting with this, LAMs were found in regions of the liver with reduced numbers of KCs, characterized by increased Desmin expression. Together, our data highlight considerable heterogeneity within the macrophage pool and suggest a need for more specific macrophage targeting strategies in MAFLD.

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Language(s): eng - English
 Dates: 2020-09-15
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: org/10.1016/j.immuni.2020.08.004
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Title: Immunity
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 53 Sequence Number: - Start / End Page: 641 - 657 Identifier: ISSN: 1074-7613
CoNE: https://pure.mpg.de/cone/journals/resource/954925604783