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  Impact of COMT val158met on tDCS-induced cognitive enhancement in older adults

Hayek, D., Antonenko, D., Witte, A. V., Lehnerer, S. M., Meinzer, M., Külzow, N., et al. (2021). Impact of COMT val158met on tDCS-induced cognitive enhancement in older adults. Behavioural Brain Research, 401: 113081. doi:10.1016/j.bbr.2020.113081.

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 Creators:
Hayek, Dayana1, 2, Author
Antonenko, Daria1, 2, Author
Witte, A. Veronica3, Author              
Lehnerer, Sophie M.2, Author
Meinzer, Marcus1, 4, Author
Külzow, Nadine2, 5, Author
Prehn, Kristin2, 6, Author
Rujescu, Dan7, Author
Schneider, Alice8, 9, Author
Grittner, Ulrike8, 9, Author
Flöel, Agnes1, 2, 10, Author
Affiliations:
1Department of Neurology, Ernst Moritz Arndt University of Greifswald, Germany, ou_persistent22              
2Charité University Medicine Berlin, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Centre for Clinical Research, University of Queensland, Brisbane, Australia, ou_persistent22              
5Clinical Research Unit, Berlin Institute of Health (BIH), Germany, ou_persistent22              
6Department of Psychology, MSH Medical School Hamburg, Germany, ou_persistent22              
7Clinic and Polyclinic for Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University Halle-Wittenberg, Germany, ou_persistent22              
8Berlin Institute of Health (BIH), Germany, ou_persistent22              
9Institute of Biometry and Clinical Epidemiology, Charité University Medicine Berlin, Germany, ou_persistent22              
10German Center for Neurodegenerative Diseases (DZNE), Greifswald, Germany, ou_persistent22              

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 Abstract: Background Previous studies suggest that genetic polymorphisms and aging modulate inter-individual variability in brain stimulation-induced plasticity. However, the relationship between genetic polymorphisms and behavioral modulation through transcranial direct current stimulation (tDCS) in older adults remains poorly understood. Objective Link individual tDCS responsiveness, operationalized as performance difference between tDCS and sham condition, to common genetic polymorphisms in healthy older adults. Methods 106 healthy older participants from five tDCS-studies were re-invited to donate blood for genotyping of apoliproprotein E (APOE: ε4 carriers and ε4 non-carriers), catechol-O-methyltransferase (COMT: val/val, val/met, met/met), brain-derived neurotrophic factor (BDNF: val/val, val/met, met/met) and KIdney/BRAin encoding gene (KIBRA: C/C, C/T, T/T). Studies had assessed cognitive performance during tDCS and sham in cross-over designs. We now asked whether the tDCS responsiveness was related to the four genotypes using a linear regression models. Results We found that tDCS responsiveness was significantly associated with COMT polymorphism; i.e., COMT val carriers (compared to met/met) showed higher tDCS responsiveness. No other significant associations emerged. Conclusion Using data from five brain stimulation studies conducted in our group, we showed that only individual variation of COMT genotypes modulated behavioral response to tDCS. These findings contribute to the understanding of inherent factors that explain inter-individual variability in functional tDCS effects in older adults, and might help to better stratify participants for future clinical trials.

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Language(s): eng - English
 Dates: 2020-11-282020-08-302020-12-142021-01-042021-03-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.bbr.2020.113081
PMID: 33359367
Other: epub 2021
 Degree: -

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Grant ID : Fl 379-10/1; Fl 379-11/1; DFG-Exc-257; An 423/1-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft
Project name : -
Grant ID : 01GQ1424A
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung
Project name : -
Grant ID : AVD115110
Funding program : -
Funding organization : Alzheimer Forschung Initiative e.V.

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Title: Behavioural Brain Research
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 401 Sequence Number: 113081 Start / End Page: - Identifier: ISSN: 0166-4328
CoNE: https://pure.mpg.de/cone/journals/resource/954925482632