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  Lipid–protein forces predict conformational changes in a mechanosensitive channel

Daday, C., & de Groot, B. L. (2021). Lipid–protein forces predict conformational changes in a mechanosensitive channel. European Biophysics Journal, 50(2), 181-186. doi:10.1007/s00249-020-01488-z.

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 Creators:
Daday, C.1, Author              
de Groot, B. L.2, Author              
Affiliations:
1Research Group of Computational Biomolecular Dynamics, MPI for Biophysical Chemistry, Max Planck Society, ou_578573              
2Research Group of Computational Biomolecular Dynamics, MPI for biophysical chemistry, Max Planck Society, ou_578573              

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Free keywords: Membrane tension, Conformational change, Ion channel, Force distribution analysis, Functional mode analysis
 Abstract: The mechanosensitive TREK-2 potassium channel, a member of the K2P family, has essential physiological roles and is, therefore, a pharmaceutical target. A combination of experimental and computational studies have established that of the two known conformations, “up” and “down”, membrane tension directly favors the “up” state, which displays a higher conductance. However, these studies did not reveal the exact mechanism by which the membrane affects the channel conformation. In this work, we show that changes in protein–lipid interaction patterns suffice in predicting this conformational change, and pinpoint potentially important residues involved in this phenomenon.

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Language(s): eng - English
 Dates: 2020-12-232021-03
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s00249-020-01488-z
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Project name : Project A03
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Funding program : SFB 803
Funding organization : DFG

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Title: European Biophysics Journal
Source Genre: Journal
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Pages: - Volume / Issue: 50 (2) Sequence Number: - Start / End Page: 181 - 186 Identifier: -