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  The genetics underlying metabolic signatures in a brown rice diversity panel and their vital role in human nutrition

Brotman, Y., Llorente-Wiegand, C., Oyong, G., Badoni, S., Misra, G., Anacleto, R., et al. (2021). The genetics underlying metabolic signatures in a brown rice diversity panel and their vital role in human nutrition. The Plant Journal, 106(2), 507-527. doi:10.1111/tpj.15182.

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Genre: Journal Article
Alternative Title : The Plant Journal

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 Creators:
Brotman, Y.1, Author              
Llorente-Wiegand, Cindy2, Author
Oyong, Glenn2, Author
Badoni, Saurabh2, Author
Misra, Gopal2, Author
Anacleto, Roslen2, Author
Parween, Sabiha2, Author
Pasion, Erstelle2, Author
Tiozon Jr., Rhowell N.2, Author
Anonuevo, Joanne J.2, Author
Krishna deGuzman, Maria2, Author
Alseekh, S.3, Author              
Mbanjo, Edwige G.N.2, Author
Boyd, Lesley A.2, Author
Fernie, A. R.4, Author              
Sreenivasulu, Nese2, Author
Affiliations:
1Genetics of Metabolic Traits, Cooperative Research Groups, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_2497694              
2external, ou_persistent22              
3The Genetics of Crop Metabolism, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_3244836              
4Central Metabolism, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753339              

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Free keywords: brown rice, catechins, cytotoxicity assay, flavonoids, glycemic index, human nutrition, metabolite genome-wide association study (mGWAS), pericarp colour
 Abstract: Summary Brown rice possesses various nutritionally dense bioactive phytochemicals exhibiting wide range of antioxidant, anticancer and antidiabetic properties known to promote various human health benefits. However, despite the wide claims made about the importance of brown rice for human nutrition the underlying metabolic diversity not systematically explored. Non-targeted metabolite profiling of developing and mature seeds of a diverse genetic panel of 320 rice cultivars allowed quantification of 117 metabolites. The metabolite genome-wide association study (mGWAS) detected genetic variants influencing diverse metabolic targets in developing and mature seeds. We further interlinked genetic variants on chromosome 7 (6.06-6.43 Mb region) with complex epistatic genetic interactions impacting multi-dimensional nutritional targets, including complex carbohydrate starch quality, glycemic index, antioxidant catechin and rice grain colour. Through this nutrigenomics approach rare gene bank accessions possessing genetic variants in bHLH and IPT5 genes were identified through haplotype enrichment. These variants were associated with low glycemic index, higher catechin, elevated total flavonoid contents and heightened antioxidant activity in the whole grain with elevated anti-cancer properties being confirmed on cancer cell lines. This multi-disciplinary nutrigenomics approach thus allowed us to discover the genetic basis of human-health conferring diversity in the metabolome of brown rice.

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Language(s): eng - English
 Dates: 2021
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/tpj.15182
 Degree: -

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Title: The Plant Journal
  Other : Plant J.
Source Genre: Journal
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Publ. Info: Oxford : Blackwell Science
Pages: - Volume / Issue: 106 (2) Sequence Number: - Start / End Page: 507 - 527 Identifier: ISSN: 0960-7412
CoNE: https://pure.mpg.de/cone/journals/resource/954925579095_1