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  Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

You, X., Vlatkovic, I., Babic, A., Will, T., Epstein, I., Tushev, G., et al. (2015). Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat Neurosci, 18(4), 603-610. doi:10.1038/nn.3975.

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You, X., Author
Vlatkovic, I., Author
Babic, A., Author
Will, T., Author
Epstein, I., Author
Tushev, G., Author
Akbalik, G., Author
Wang, M., Author
Glock, C., Author
Quedenau, C., Author
Wang, X., Author
Hou, J., Author
Liu, H., Author
Sun, W., Author
Sambandan, S., Author
Chen, T., Author
Schuman, Erin M.1, Author           
Chen, W., Author
Affiliations:
1Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society, ou_2461710              

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Free keywords: Animals Brain/growth & development/*metabolism Dendrites/*metabolism Female Hippocampus/metabolism In Situ Hybridization Male Mice Mice, Inbred C57BL Neuronal Plasticity/*physiology Neuropil/*metabolism Patch-Clamp Techniques RNA/*metabolism RNA, Circular Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, RNA Synapses/*genetics
 Abstract: Circular RNAs (circRNAs) have re-emerged as an interesting RNA species. Using deep RNA profiling in different mouse tissues, we observed that circRNAs were substantially enriched in brain and a disproportionate fraction of them were derived from host genes that encode synaptic proteins. Moreover, on the basis of separate profiling of the RNAs localized in neuronal cell bodies and neuropil, circRNAs were, on average, more enriched in the neuropil than their host gene mRNA isoforms. Using high-resolution in situ hybridization, we visualized circRNA punctae in the dendrites of neurons. Consistent with the idea that circRNAs might regulate synaptic function during development, many circRNAs changed their abundance abruptly at a time corresponding to synaptogenesis. In addition, following a homeostatic downscaling of neuronal activity many circRNAs exhibited substantial up- or downregulation. Together, our data indicate that brain circRNAs are positioned to respond to and regulate synaptic function.

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 Dates: 2015-02-26
 Publication Status: Issued
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 Identifiers: Other: 25714049
DOI: 10.1038/nn.3975
ISSN: 1546-1726 (Electronic)1097-6256 (Linking)
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Title: Nat Neurosci
Source Genre: Journal
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Pages: - Volume / Issue: 18 (4) Sequence Number: - Start / End Page: 603 - 610 Identifier: -