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  Protein synthesis at synaptic sites on dendrites

Steward, O., & Schuman, E. M. (2001). Protein synthesis at synaptic sites on dendrites. Annu Rev Neurosci, 24, 299-325.

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Steward, O., Author
Schuman, Erin M.1, Author           
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1Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society, ou_2461710              

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Free keywords: Animals Dendrites/*physiology Hippocampus/*physiology Humans Long-Term Potentiation Nerve Tissue Proteins/biosynthesis/*genetics Neuronal Plasticity Protein Biosynthesis RNA, Messenger/genetics Synapses/*physiology Transcription, Genetic
 Abstract: Studies over the past 20 years have revealed that gene expression in neurons is carried out by a distributed network of translational machinery. One component of this network is localized in dendrites, where polyribosomes and associated membranous elements are positioned beneath synapses and translate a particular population of dendritic mRNAs. The localization of translation machinery and mRNAs at synapses endows individual synapses with the capability to independently control synaptic strength through the local synthesis of proteins. The present review discusses recent studies linking synaptic plasticity to dendritic protein synthesis and mRNA trafficking and considers how these processes are regulated. We summarize recent information about how synaptic signaling is coupled to local translation and to the delivery of newly transcribed mRNAs to activated synaptic sites and how local translation may play a role in activity-dependent synaptic modification.

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 Dates: 2001-04-03
 Publication Status: Issued
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 Identifiers: Other: 11283313
DOI: 10.1146/annurev.neuro.24.1.299
ISSN: 0147-006X (Print)0147-006X (Linking)
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Title: Annu Rev Neurosci
Source Genre: Journal
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Pages: - Volume / Issue: 24 Sequence Number: - Start / End Page: 299 - 325 Identifier: -