English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue

Kantor, D. B., Lanzrein, M., Stary, S. J., Sandoval, G. M., Smith, W. B., Sullivan, B. M., et al. (1996). A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue. Science, 274(5293), 1744-8. doi:10.1126/science.274.5293.1744.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Kantor, D. B., Author
Lanzrein, M., Author
Stary, S. J., Author
Sandoval, G. M., Author
Smith, W. B., Author
Sullivan, B. M., Author
Davidson, N., Author
Schuman, Erin M.1, Author              
Affiliations:
1Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society, ou_2461710              

Content

show
hide
Free keywords: Adenoviridae/genetics Animals CHO Cells Cell Membrane/enzymology Cricetinae Cytosol/enzymology Endothelium/*enzymology Genetic Vectors Hippocampus/*physiology In Vitro Techniques *Long-Term Potentiation/drug effects Mice Myristic Acid Myristic Acids/metabolism/pharmacology Neurons/*physiology Nitric Oxide Synthase/genetics/*metabolism Recombinant Fusion Proteins/metabolism Synaptic Transmission Transfection
 Abstract: Pharmacological studies support the idea that nitric oxide (NO) serves as a retrograde messenger during long-term potentiation (LTP) in area CA1 of the hippocampus. Mice with a defective form of the gene for neuronal NO synthase (nNOS), however, exhibit normal LTP. The myristoyl protein endothelial NOS (eNOS) is present in the dendrites of CA1 neurons. Recombinant adenovirus vectors containing either a truncated eNOS (a putative dominant negative) or an eNOS fused to a transmembrane protein were used to demonstrate that membrane-targeted eNOS is required for LTP. The membrane localization of eNOS may optimally position the enzyme both to respond to Ca2+ influx and to release NO into the extracellular space during LTP induction.

Details

show
hide
Language(s):
 Dates: 1996-12-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: 8939872
DOI: 10.1126/science.274.5293.1744
ISSN: 0036-8075 (Print)0036-8075 (Linking)
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Science
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 274 (5293) Sequence Number: - Start / End Page: 1744 - 8 Identifier: -