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  A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity

Kang, H., & Schuman, E. M. (1996). A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity. Science, 273(5280), 1402-6. doi:10.1126/science.273.5280.1402.

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Kang, H., Author
Schuman, Erin M.1, Author           
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1Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society, ou_2461710              

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Free keywords: Animals Anisomycin/pharmacology Axons/metabolism Brain-Derived Neurotrophic Factor Chloramphenicol/pharmacology Cycloheximide/pharmacology Dendrites/metabolism Hippocampus/drug effects/metabolism/*physiology In Vitro Techniques Male Nerve Growth Factors/*pharmacology Nerve Tissue Proteins/*pharmacology *Neuronal Plasticity Neurotrophin 3 *Protein Biosynthesis Protein Synthesis Inhibitors/pharmacology Pyramidal Cells/drug effects/metabolism/physiology Rats Rats, Sprague-Dawley Synaptic Transmission/*drug effects
 Abstract: Two neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are able to produce a long-lasting enhancement of synaptic transmission in the hippocampus. Unlike other forms of plasticity, neurotrophin-induced plasticity exhibited an immediate requirement for protein synthesis. Plasticity in rat hippocampal slices in which the synaptic neuropil was isolated from the principal cell bodies also required early protein synthesis. Thus, the neurotrophins may stimulate the synthesis of proteins in either axonal or dendritic compartments, allowing synapses to exert local control over the complement of proteins expressed at individual synaptic sites.

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 Dates: 1996-09-06
 Publication Status: Issued
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 Identifiers: Other: 8703078
DOI: 10.1126/science.273.5280.1402
ISSN: 0036-8075 (Print)0036-8075 (Linking)
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Title: Science
Source Genre: Journal
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Pages: - Volume / Issue: 273 (5280) Sequence Number: - Start / End Page: 1402 - 6 Identifier: -