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Free keywords:
Animals
Anisomycin/pharmacology
Axons/metabolism
Brain-Derived Neurotrophic Factor
Chloramphenicol/pharmacology
Cycloheximide/pharmacology
Dendrites/metabolism
Hippocampus/drug effects/metabolism/*physiology
In Vitro Techniques
Male
Nerve Growth Factors/*pharmacology
Nerve Tissue Proteins/*pharmacology
*Neuronal Plasticity
Neurotrophin 3
*Protein Biosynthesis
Protein Synthesis Inhibitors/pharmacology
Pyramidal Cells/drug effects/metabolism/physiology
Rats
Rats, Sprague-Dawley
Synaptic Transmission/*drug effects
Abstract:
Two neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are able to produce a long-lasting enhancement of synaptic transmission in the hippocampus. Unlike other forms of plasticity, neurotrophin-induced plasticity exhibited an immediate requirement for protein synthesis. Plasticity in rat hippocampal slices in which the synaptic neuropil was isolated from the principal cell bodies also required early protein synthesis. Thus, the neurotrophins may stimulate the synthesis of proteins in either axonal or dendritic compartments, allowing synapses to exert local control over the complement of proteins expressed at individual synaptic sites.