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  Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells

Schulien, I., Kemming, J., Oberhardt, V., Wild, K., Seidel, L. M., Killmer, S., et al. (2020). Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells. Nature Medicine, 27, 78-85. doi:10.1038/s41591-020-01143-2.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-ED08-6 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-BD5E-6
Genre: Journal Article

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2020
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https://www.nature.com/articles/s41591-020-01143-2 (Publisher version)
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 Creators:
Schulien, Isabel1, Author
Kemming, Janine1, Author
Oberhardt, Valerie1, Author
Wild, Katharina1, Author
Seidel, Lea M1, Author
Killmer, Saskia1, Author
Sagar2, Author
Daul, Franziska1, Author
Lago, Marilyn Salvat1, Author
Decker, Annegrit1, Author
Luxenburger, Hendrik1, Author
Binder, Benedikt1, Author
Bettinger, Dominik1, Author
Sogukpinar, Oezlem1, Author
Rieg, Siegbert1, Author
Panning, Marcus1, Author
Huzly, Daniela1, Author
Schwemmle, Martin1, Author
Kochs, Georg1, Author
Waller, Cornelius F1, Author
more..
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_persistent22              

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 Abstract: Emerging data indicate that SARS-CoV-2-specific CD8+ T cells targeting different viral proteins are detectable in up to 70% of convalescent individuals. However, very little information is currently available about the abundance, phenotype, functional capacity and fate of pre-existing and induced SARS-CoV-2-specific CD8+ T cell responses during the natural course of SARS-CoV-2 infection. Here, we define a set of optimal and dominant SARS-CoV-2-specific CD8+ T cell epitopes. We also perform a high-resolution ex vivo analysis of pre-existing and induced SARS-CoV-2-specific CD8+ T cells, applying peptide-loaded major histocompatibility complex class I (pMHCI) tetramer technology. We observe rapid induction, prolonged contraction and emergence of heterogeneous and functionally competent cross-reactive and induced memory CD8+ T cell responses in cross-sectionally analyzed individuals with mild disease following SARS-CoV-2 infection and three individuals longitudinally assessed for their T cells pre- and post-SARS-CoV-2 infection. SARS-CoV-2-specific memory CD8+ T cells exhibited functional characteristics comparable to influenza-specific CD8+ T cells and were detectable in SARS-CoV-2 convalescent individuals who were seronegative for anti-SARS-CoV-2 antibodies targeting spike (S) and nucleoprotein (N). These results define cross-reactive and induced SARS-CoV-2-specific CD8+ T cell responses as potentially important determinants of immune protection in mild SARS-CoV-2 infection.

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Language(s): eng - English
 Dates: 2020-11-12
 Publication Status: Published online
 Pages: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41591-020-01143-2
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Title: Nature Medicine
  Other : Nat. Med.
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Co.
Pages: - Volume / Issue: 27 Sequence Number: - Start / End Page: 78 - 85 Identifier: ISSN: 1078-8956
CoNE: https://pure.mpg.de/cone/journals/resource/954925606824