English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Reliable Sequential Activation of Neural Assemblies by Single Pyramidal Cells in a Three-Layered Cortex

Hemberger, M., Shein-Idelson, M., Pammer, L., & Laurent, G. (2019). Reliable Sequential Activation of Neural Assemblies by Single Pyramidal Cells in a Three-Layered Cortex. Neuron, 104(2), 353-369 e5. doi:10.1016/j.neuron.2019.07.017.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Hemberger, M., Author
Shein-Idelson, M., Author
Pammer, L., Author
Laurent, Gilles1, Author              
Affiliations:
1Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society, ou_2461701              

Content

show
hide
Free keywords: Action Potentials/*physiology Animals Cerebral Cortex/physiology Electric Stimulation Interneurons/*physiology Microelectrodes Neurons/physiology Optogenetics Patch-Clamp Techniques Pyramidal Cells/*physiology Turtles Visual Cortex/*physiology *birdsong *cortex *dynamics *replay *sequences *synfire *turtle
 Abstract: Recent studies reveal the occasional impact of single neurons on surround firing statistics and even simple behaviors. Exploiting the advantages of a simple cortex, we examined the influence of single pyramidal neurons on surrounding cortical circuits. Brief activation of single neurons triggered reliable sequences of firing in tens of other excitatory and inhibitory cortical neurons, reflecting cascading activity through local networks, as indicated by delayed yet precisely timed polysynaptic subthreshold potentials. The evoked patterns were specific to the pyramidal cell of origin, extended over hundreds of micrometers from their source, and unfolded over up to 200 ms. Simultaneous activation of pyramidal cell pairs indicated balanced control of population activity, preventing paroxysmal amplification. Single cortical pyramidal neurons can thus trigger reliable postsynaptic activity that can propagate in a reliable fashion through cortex, generating rapidly evolving and non-random firing sequences reminiscent of those observed in mammalian hippocampus during "replay" and in avian song circuits.

Details

show
hide
Language(s):
 Dates: 2019-08-24
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: 31439429
DOI: 10.1016/j.neuron.2019.07.017
ISSN: 1097-4199 (Electronic)0896-6273 (Linking)
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neuron
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 104 (2) Sequence Number: - Start / End Page: 353 - 369 e5 Identifier: -