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  Intrinsic and circuit properties favor coincidence detection for decoding oscillatory input

Perez-Orive, J., Bazhenov, M., & Laurent, G. (2004). Intrinsic and circuit properties favor coincidence detection for decoding oscillatory input. J Neurosci, 24(26), 6037-47. doi:10.1523/JNEUROSCI.1084-04.2004.

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Perez-Orive, J., Author
Bazhenov, M., Author
Laurent, Gilles1, Author              
Affiliations:
1Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society, ou_2461701              

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Free keywords: Action Potentials Animals Biological Clocks/*physiology Dendrites/physiology Excitatory Postsynaptic Potentials/physiology Female Grasshoppers/*physiology Male Models, Neurological Mushroom Bodies/*physiology Nerve Net/physiology Neurons/*physiology Odorants Sense Organs/*physiology Smell/*physiology Time Factors
 Abstract: In the insect olfactory system the antennal lobe generates oscillatory synchronization of its output as a framework for coincidence detection by its target, the mushroom body (MB). The intrinsic neurons of the MB (Kenyon cells, KCs) are thus a good model system in which to investigate the functional relevance of oscillations and neural synchronization. We combine electrophysiological and modeling approaches to examine how intrinsic and circuit properties might contribute to the preference of KCs for coincident input and how their decoding of olfactory information is affected by the absence of oscillatory synchronization in their input. We show that voltage-dependent subthreshold properties of KCs bring about a supralinear summation of their inputs, favoring responses to coincident EPSPs. Abolishing oscillatory synchronization weakens the preference of KCs for coincident input and causes a large reduction in their odor specificity. Finally, we find that a decoding strategy that is based on coincidence detection enhances both noise tolerance and input discriminability by KCs.

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 Dates: 2004-07-02
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: Other: 15229251
DOI: 10.1523/JNEUROSCI.1084-04.2004
ISSN: 1529-2401 (Electronic)0270-6474 (Linking)
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Title: J Neurosci
Source Genre: Journal
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Pages: - Volume / Issue: 24 (26) Sequence Number: - Start / End Page: 6037 - 47 Identifier: -