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  Neural Basis of Impaired Emotion Recognition in Adult Attention-Deficit/Hyperactivity Disorder

Zuberer, A., Schwarz, L., Kreifelts, B., Wildgruber, D., Erb, M., Fallgatter, A., et al. (2020). Neural Basis of Impaired Emotion Recognition in Adult Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Epub ahead. doi:10.1016/j.bpsc.2020.11.013.

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Zuberer, A, Author
Schwarz, L, Author
Kreifelts, B, Author
Wildgruber, D, Author
Erb, M, Author              
Fallgatter, A, Author
Scheffler, K1, 2, Author              
Ethofer, T, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Background: Deficits in emotion recognition have been repeatedly documented in patients diagnosed with attention-deficit/hyperactivity disorder (ADHD), but their neural basis is unknown so far. Methods: In the current study, adult patients with ADHD (n = 44) and healthy control subjects (n = 43) underwent functional magnetic resonance imaging during explicit emotion recognition of stimuli expressing affective information in face, voice, or face-voice combinations. The employed experimental paradigm allowed us to delineate areas for processing audiovisual information based on their functional activation profile, including the bilateral posterior superior temporal gyrus/middle temporal gyrus, amygdala, medial prefrontal cortex, and precuneus, as well as the right posterior thalamus. Results: As expected, unbiased hit rates for correct classification of the expressed emotions were lower in patients with ADHD than in healthy control subjects irrespective of the presented sensory modality. This deficit at a behavioral level was accompanied by lower activation in patients with ADHD versus healthy control subjects in the cortex adjacent to the right superior temporal gyrus/middle temporal gyrus and the right posterior thalamus, which represent key areas for processing socially relevant signals and their integration across modalities. A cortical region adjacent to the right posterior superior temporal gyrus was the only brain region that showed a significant correlation between brain activation and emotion identification performance. Conclusions: Altogether, these results provide the first evidence for a potential neural substrate of the observed impairments in emotion recognition in adults with ADHD.

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 Dates: 2020-11
 Publication Status: Published online
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1016/j.bpsc.2020.11.013
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Title: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: Epub ahead Sequence Number: - Start / End Page: - Identifier: ISSN: 2451-9022
CoNE: https://pure.mpg.de/cone/journals/resource/2451-9022