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キーワード:
Animals
Aspartic Acid/physiology
Brain Waves/physiology
CA1 Region, Hippocampal/*anatomy & histology
Cortical Synchronization/physiology
Executive Function/physiology
Glutamic Acid/physiology
Humans
Interneurons/physiology
Maze Learning/physiology
Memory, Short-Term/*physiology
Midline Thalamic Nuclei/*anatomy & histology/physiology
Nerve Net/physiology
Neural Pathways/anatomy & histology/physiology
Neurons/physiology
Prefrontal Cortex/*anatomy & histology
Rats
Spatial Navigation/*physiology
Synaptic Transmission
要旨:
The nucleus reuniens of the thalamus (RE) is a key component of an extensive network of hippocampal and cortical structures and is a fundamental substrate for cognition. A common misconception is that RE is a simple relay structure. Instead, a better conceptualization is that RE is a critical component of a canonical higher-order cortico-thalamo-cortical circuit that supports communication between the medial prefrontal cortex (mPFC) and the hippocampus (HC). RE dysfunction is implicated in several clinical disorders including, but not limited to Alzheimer's disease, schizophrenia, and epilepsy. Here, we review key anatomical and physiological features of the RE based primarily on studies in rodents. We present a conceptual model of RE circuitry within the mPFC-RE-HC system and speculate on the computations RE enables. We review the rapidly growing literature demonstrating that RE is critical to, and its neurons represent, aspects of behavioral tasks that place demands on memory focusing on its role in navigation, spatial working memory, the temporal organization of memory, and executive functions.
