ausblenden:
Schlagwörter:
Animals
Axons/physiology
CA1 Region, Hippocampal/cytology/*physiology
Entorhinal Cortex/cytology/*physiology
Humans
Models, Neurological
Neural Pathways/physiology
Ca1
Direct pathway
Entorhinal cortex
Hippocampus
Transverse axis
Zusammenfassung:
Decades of neuroscience research have shed light on the hippocampus as a key structure for the formation of episodic memory. The hippocampus is divided into distinct subfields - CA1, CA2 and CA3. While accumulating evidence points to cellular and synaptic heterogeneity within each subfield, this heterogeneity has not received much attention in computational and behavioural studies and subfields have until recently been considered functionally uniform. However, a couple of recent studies have demonstrated prominent functional differences along the proximodistal axis of the CA1 subfield. Here, we review anatomical and physiological differences that might give rise to heterogeneity along the proximodistal axis of CA1 as well as the functional implications of such heterogeneity. We suggest that such heterogeneity in CA1 operates dynamically in the sense that the CA1 network alternates, on a subsecond scale, between a state where the network is primarily responsive to functionally segregated direct inputs from entorhinal cortex and a state where cells predominantly are controlled by more integrated inputs from CA3.
