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  Zwitterionic character and lipid composition determine the behaviour of GPI fragments in monolayers

Malik, A., Seeberger, P. H., Brezesinski, G., & Varón Silva, D. (2021). Zwitterionic character and lipid composition determine the behaviour of GPI fragments in monolayers. ChemPhysChem, 22(8), 757-763. doi:10.1002/cphc.202100002.

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 Creators:
Malik, Ankita1, Author              
Seeberger, Peter H.2, Author              
Brezesinski, Gerald3, Author              
Varón Silva, Daniel1, Author              
Affiliations:
1Daniel Varón Silva, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863302              
2Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              
3Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863286              

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Free keywords: Glycosylphosphatidylinositol; Monolayers; Glycolipids; GPI Modifications; Lipids
 Abstract: Glycosylphosphatidylinositols (GPIs) are complex glycolipids found in free form or anchoring proteins to the outer leaflet of the cell membrane in eukaryotes. GPIs have been associated with the formation of lipid rafts and protein sorting on membranes. The presence of a conserved glycan core of cell-specific modifications together with lipid remodeling during biosynthesis suggest that the properties of the glycolipids are being fine tuned. We synthesized a series of GPI fragments and evaluated the interactions and arrangement of these glycolipids in monolayers as a 2-D membrane model. GIXD and IRRAS analyses showed the need of N-acetylglucosamine deacetylation for the formation of hydrogen bonds to obtain highly-structured domains in the monolayers and an effect of the unsaturated lipids in formation and localization of the glycolipids within or between membrane microdomains. These results contribute to understand the role of these glycolipids and their modifications in the organization of membranes.

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Language(s): eng - English
 Dates: 2021-02-152021
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/cphc.202100002
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Title: ChemPhysChem
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 22 (8) Sequence Number: - Start / End Page: 757 - 763 Identifier: ISSN: 1439-4235