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  Altered contextual modulation of primary visual cortex responses in schizophrenia

Seymour, K., Stein, T., Olivier Sanders, L., Guggenmos, M., Theophil, I., & Sterzer, P. (2013). Altered contextual modulation of primary visual cortex responses in schizophrenia. Neuropsychopharmacology, 38(13), 2607-2612. doi:10.1038/npp.2013.168.

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Genre: Journal Article

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https://www.nature.com/articles/npp2013168.pdf (Publisher version)
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 Creators:
Seymour, K1, Author           
Stein, T, Author
Olivier Sanders, LL, Author
Guggenmos, M, Author
Theophil, I, Author
Sterzer, P, Author
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1External Organizations, ou_persistent22              

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 Abstract: Schizophrenia is typically associated with higher-level cognitive symptoms, such as disorganized thoughts, delusions, and hallucinations. However, deficits in visual processing have been consistently reported with the illness. Here, we provide strong neurophysiological evidence for a marked perturbation at the earliest level of cortical visual processing in patients with paranoid schizophrenia. Using functional magnetic resonance imaging (fMRI) and adapting a well-established approach from electrophysiology, we found that orientation-specific contextual modulation of cortical responses in human primary visual cortex (V1)--a hallmark of early neural encoding of visual stimuli--is dramatically reduced in patients with schizophrenia. This indicates that contextual processing in schizophrenia is altered at the earliest stages of visual cortical processing and supports current theories that emphasize the role of abnormalities in perceptual synthesis (eg, false inference) in schizophrenia.

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 Dates: 2013-12
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1038/npp.2013.168
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Title: Neuropsychopharmacology
  Other : Neuropsychopharmacology: off. publ. of the American College of Neuropsychopharmacology
  Abbreviation : Neuropsychopharmacol
Source Genre: Journal
 Creator(s):
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Publ. Info: New York, NY : Springer Nature
Pages: - Volume / Issue: 38 (13) Sequence Number: - Start / End Page: 2607 - 2612 Identifier: ISSN: 0893-133X
CoNE: https://pure.mpg.de/cone/journals/resource/954925558485