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  Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders

Yu, Q., He, Z., Zubkov, D., Huang, S., Kurochkin, I., Yang, X., et al. (2020). Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders. Molecular Psychiatry, 25(11), 2952-2969. doi:10.1038/s41380-018-0200-8.

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Yu, Qianhui1, Author
He, Zhisong1, Author
Zubkov, Dmitry1, Author
Huang, Shuyun1, Author
Kurochkin, Ilia1, Author
Yang, Xiaode1, Author
Halene, Tobias1, Author
Willmitzer, L.2, Author              
Giavalisco, P.3, Author              
Akbarian, Schahram1, Author
Khaitovich, Philipp1, Author
Affiliations:
1external, ou_persistent22              
2Small Molecules, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753340              
3Experimental Systems Biology, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753342              

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 Abstract: Lipids are essential to brain functions, yet they remain largely unexplored. Here we investigated the lipidome composition of prefrontal cortex gray matter in 396 cognitively healthy individuals with ages spanning 100 years, as well as 67 adult individuals diagnosed with autism (ASD), schizophrenia (SZ), and Down syndrome (DS). Of the 5024 detected lipids, 95% showed significant age-dependent concentration differences clustering into four temporal stages, and resulting in a gradual increase in membrane fluidity in individuals ranging from newborn to nonagenarian. Aging affects 14% of the brain lipidome with late-life changes starting predominantly at 50-55 years of age-a period of general metabolic transition. All three diseases alter the brain lipidome composition, leading-among other things-to a concentration decrease in glycerophospholipid metabolism and endocannabinoid signaling pathways. Lipid concentration decreases in SZ were further linked to genetic variants associated with disease, indicating the relevance of the lipidome changes to disease progression.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: ISI: 000611534000024
DOI: 10.1038/s41380-018-0200-8
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Title: Molecular Psychiatry
Source Genre: Journal
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Publ. Info: Houndmills, Hampshire, UK : Stockton Press
Pages: - Volume / Issue: 25 (11) Sequence Number: - Start / End Page: 2952 - 2969 Identifier: ISSN: 1359-4184
CoNE: https://pure.mpg.de/cone/journals/resource/954925619131