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  In vitro efficacy of Artemisia extracts against SARS-CoV-2

Nie, C., Trimpert, J., Moon, S.-Y., Haag, R., Gilmore, K., Kaufer, B. B., et al. (2021). In vitro efficacy of Artemisia extracts against SARS-CoV-2. Virology Journal, 18: 182. doi:10.1186/s12985-021-01651-8.

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 Urheber:
Nie, Chuanxiong, Autor
Trimpert, Jakob, Autor
Moon, Soo-Yeon1, Autor           
Haag, Rainer, Autor
Gilmore, Kerry1, Autor           
Kaufer, Benedikt B., Autor
Seeberger, Peter H.2, Autor           
Affiliations:
1Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863304              
2Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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Schlagwörter: Artemisia annua, Artemisia afra, antivirals, COVID-19, Covid-organics, Feline coronavirus (FCoV), SARS-CoV-2
 Zusammenfassung: Traditional medicines based on herbal extracts have been proposed as affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Teas and drinks containing extracts of Artemisia annua and Artemisia afra have been widely used in Africa in efforts to prevent and fight COVID-19 infections. We sought to study the ability of different A. annua and A. afra extracts and the Covid-Organics drink produced in Madagascar to inhibit SARS-CoV-2 and feline coronavirus (FCoV) replication in vitro. Several extracts as well as Covid-Organics inhibit SARS-CoV-2 and FCoV replication at concentrations that did not affect cell viability. It remains unclear whether peak plasma concentrations in humans can reach levels needed to inhibit viral replication following consumption of teas or Covid-Organics. Clinical studies are required to evaluate the utility of these drinks for COVID-19 prevention or treatment in patients.Competing Interest StatementK.G. is the director of ArtemiLife, Inc. K.G. and P.H.S. have a significant financial stake in ArtemiFlow GmbH, that is a shareholder in ArtemiLife, Inc. All other authors have no competing/conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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Sprache(n): eng - English
 Datum: 2021-09-082021
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1186/s12985-021-01651-8
DOI: 10.1101/2021.02.14.431122
BibTex Citekey: Nie2021.02.14.431122
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Titel: Virology Journal
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: BioMed Central
Seiten: - Band / Heft: 18 Artikelnummer: 182 Start- / Endseite: - Identifikator: ISSN: 1743-422X

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Titel: bioRxiv
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: Cold Spring Harbor : Cold Spring Harbor Laboratory
Seiten: - Band / Heft: - Artikelnummer: 2021.02.14.431122 Start- / Endseite: - Identifikator: ZDB: 2766415-6