English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Flavins in the electron bifurcation process

Kayastha, K., Vitt, S., Buckel, W., & Ermler, U. (2021). Flavins in the electron bifurcation process. Archives of Biochemistry and Biophysics, 701: 108796. doi:10.1016/j.abb.2021.108796.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Kayastha, Kanwal1, Author              
Vitt, Stella1, 2, Author              
Buckel, Wolfgang2, 3, Author              
Ermler, Ulrich1, Author              
Affiliations:
1Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068290              
2Laboratorium für Mikrobiologie, Fachbereich Biologie and SYNMIKRO, Philipps-Universität, 35032, Marburg, Germany, ou_persistent22              
3Max Planck Fellow Mechanism of Enzymes from Anaerobic Bacteria, Alumni, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, ou_3266319              

Content

show
hide
Free keywords: Bioenergetics; Electron bifurcation; Electron transfer; Flavin; Redox reactions
 Abstract: The discovery of a new energy-coupling mechanism termed flavin-based electron bifurcation (FBEB) in 2008 revealed a novel field of application for flavins in biology. The key component is the bifurcating flavin endowed with strongly inverted one-electron reduction potentials (FAD/FAD•- ≪ FAD•-/FADH-) that cooperatively transfers in its reduced state one low and one high-energy electron into different directions and thereby drives an endergonic with an exergonic reduction reaction. As energy splitting at the bifurcating flavin apparently implicates one-electron chemistry, the FBEB machinery has to incorporate prior to and behind the central bifurcating flavin 2e-to-1e and 1e-to-2e switches, frequently also flavins, for oxidizing variable medium-potential two-electron donating substrates and for reducing high-potential two-electron accepting substrates. The one-electron carriers ferredoxin or flavodoxin serve as low-potential (high-energy) electron acceptors, which power endergonic processes almost exclusively in obligate anaerobic microorganisms to increase the efficiency of their energy metabolism. In this review, we outline the global organization of FBEB enzymes, the functions of the flavins therein and the surrounding of the isoalloxazine rings by which their reduction potentials are specifically adjusted in a finely tuned energy landscape.

Details

show
hide
Language(s): eng - English
 Dates: 2021-02-012020-10-302021-02-032021-02-182021-04-15
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.abb.2021.108796
PMID: 33609536
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Archives of Biochemistry and Biophysics
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Academic Press
Pages: - Volume / Issue: 701 Sequence Number: 108796 Start / End Page: - Identifier: ISSN: 0003-9861
CoNE: https://pure.mpg.de/cone/journals/resource/991042745826956