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  Immediate and longitudinal effects of maltreatment on systemic inflammation in young children

Entringer, S., de Punder, K., Overfeld, J., Karaboycheva, G., Dittrich, K., Buss, C., et al. (2020). Immediate and longitudinal effects of maltreatment on systemic inflammation in young children. Development and Psychopathology, 32(5), 1725-1731. doi:10.1017/S0954579420001686.

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 Creators:
Entringer, Sonja, Author
de Punder, Karin, Author
Overfeld, Judith, Author
Karaboycheva, Gergana, Author
Dittrich, Katja, Author
Buss, Claudia, Author
Winter, Sibylle Maria, Author
Binder, Elisabeth B.1, Author           
Heim, Christine, Author
Affiliations:
1Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, Kraepelinstr. 2-10, 80804 Munich, DE, ou_2035295              

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Free keywords: ADVERSE CHILDHOOD EXPERIENCES; C-REACTIVE PROTEIN; SEX-DIFFERENCES; PSYCHOLOGICAL STRESS; RESPONSES; HEALTH; BRAIN; TRAJECTORIES; ADOLESCENTS; MECHANISMSPsychology; CRP; early life stress; inflammation; maltreatment; sex differences;
 Abstract: Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence for the link between early adverse exposures and inflammation have been retrospective or cross-sectional in design, or did not assess inflammation immediately after maltreatment in young children. In the present study we investigated the association between childhood maltreatment and salivary C-reactive protein (CRP) concentrations in a population of N = 173 children, 3-5 years of age, who were recruited in the immediate aftermath of maltreatment and followed-up longitudinally every 6 months over a period of 2 years. We found that the association between maltreatment and CRP concentrations was significantly moderated by child sex, such that in girls, CRP concentrations were higher in the maltreated compared to the control group, and this difference was stable across the 2-year follow-up-period, while in boys, there was no association between maltreatment and CRP. Our findings suggest that the effect of maltreatment on inflammation may already emerge right after exposure at a very young age in girls and manifest over time. Our study provides important evidence for the development of personalized, early interventions strategies targeting the early-life period.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Issued
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000607295100012
DOI: 10.1017/S0954579420001686
 Degree: -

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Title: Development and Psychopathology
Source Genre: Journal
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Publ. Info: New York, NY : Cambridge Univ. Press
Pages: - Volume / Issue: 32 (5) Sequence Number: - Start / End Page: 1725 - 1731 Identifier: ISSN: 0954-5794
CoNE: https://pure.mpg.de/cone/journals/resource/0954-5794