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  Pupil Dilation during Reward Anticipation Is Correlated to Depressive Symptom Load in Patients with Major Depressive Disorder

Schneider, M., Elbau, I., Nantawisarakul, T., Poehlchen, D., Bruckl, T., Czisch, M., et al. (2020). Pupil Dilation during Reward Anticipation Is Correlated to Depressive Symptom Load in Patients with Major Depressive Disorder. BRAIN SCIENCES, 10(12): 906. doi:10.3390/brainsci10120906.

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 Creators:
Schneider, Max1, Author           
Elbau, Immanuel1, Author           
Nantawisarakul, Taechawidd1, Author           
Poehlchen, Dorothee1, Author           
Bruckl, Tanja1, Author           
Czisch, Michael2, Author           
Saemann, Philipp G.2, Author           
Lee, Michael D., Author
Binder, Elisabeth B.1, Author           
Spoormaker, Victor I.1, Author           
Affiliations:
1Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, Kraepelinstr. 2-10, 80804 Munich, DE, ou_2035295              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: TEST-RETEST RELIABILITY; DEFAULT MODE NETWORK; EMOTIONAL INFORMATION; LOCUS-COERULEUS; LIGHT REFLEX; ACUTE STRESS; DYSFUNCTION; REACTIVITY; ANHEDONIA; CIRCUITNeurosciences & Neurology; depression; arousal; reward; pupillometry; fMRI;
 Abstract: Depression is a debilitating disorder with high prevalence and socioeconomic cost, but the brain-physiological processes that are altered during depressive states are not well understood. Here, we build on recent findings in macaques that indicate a direct causal relationship between pupil dilation and anterior cingulate cortex mediated arousal during anticipation of reward. We translated these findings to human subjects with concomitant pupillometry/fMRI in a sample of unmedicated participants diagnosed with major depression and healthy controls. We could show that the upregulation and maintenance of arousal in anticipation of reward was disrupted in patients in a symptom-load dependent manner. We could further show that the failure to maintain reward anticipatory arousal showed state-marker properties, as it tracked the load and impact of depressive symptoms independent of prior diagnosis status. Further, group differences of anticipatory arousal and continuous correlations with symptom load were not traceable only at the level of pupillometric responses, but were mirrored also at the neural level within salience network hubs. The upregulation and maintenance of arousal during reward anticipation is a novel translational and well-traceable process that could prove a promising gateway to a physiologically informed patient stratification and targeted interventions.

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Language(s): eng - English
 Dates: 2020-11-25
 Publication Status: Published online
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000601841200001
DOI: 10.3390/brainsci10120906
 Degree: -

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Title: BRAIN SCIENCES
Source Genre: Journal
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Publ. Info: ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND : MDPI
Pages: - Volume / Issue: 10 (12) Sequence Number: 906 Start / End Page: - Identifier: -