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  Childhood exposure to hunger: associations with health outcomes in later life and epigenetic markers

Perna, L., Zhang, Y., Wild, B., Kliegel, M., Ihle, A., Schoettker, B., et al. (2020). Childhood exposure to hunger: associations with health outcomes in later life and epigenetic markers. EPIGENOMICS, 12(21), 1861-1870. doi:10.2217/epi-2019-0333.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0008-2766-A Versions-Permalink: https://hdl.handle.net/21.11116/0000-0008-C72C-7
Genre: Zeitschriftenartikel

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 Urheber:
Perna, Laura1, Autor           
Zhang, Yan, Autor
Wild, Beate, Autor
Kliegel, Matthias, Autor
Ihle, Andreas, Autor
Schoettker, Ben, Autor
Mons, Ute, Autor
Brenner, Hermann, Autor
Affiliations:
1Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, Kraepelinstr. 2-10, 80804 Munich, DE, ou_2035295              

Inhalt

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Schlagwörter: DEPRESSIVE-SYMPTOMS; CHILDRENS HEALTH; FAMINE; CONSEQUENCES; ADULTHOODGenetics & Heredity; cardiovascular disease; childhood hunger; depressive symptoms; DNA methylation; early-life adversity; epigenetics; EWAS; German famine; late-life depression; older adults;
 Zusammenfassung: Aim: To assess associations of early exposure to hunger with depressive symptoms and cardiovascular disease (CVD) and to investigate possible epigenetic pathways. Patients & methods: Data were based on a German population-based cohort of older adults (n = 9631). Regression models were performed for health outcomes in later life. An epigenome-wide association study for early-life exposure to hunger was performed in a subgroup (n = 2221) with whole blood DNA methylation data. Results: Childhood exposure to hunger was associated with CVD and depressive symptoms in later life. Prenatal or infant exposure was strongly associated with depressive symptoms. No CpG reached epigenome-wide significance after multiple testing correction. Conclusion: Childhood hunger is a risk factor for depressive symptoms and CVD at older age. DNA methylation could not explain this association.

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Sprache(n): eng - English
 Datum: 2020-11-202020
 Publikationsstatus: Erschienen
 Seiten: 10
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000591488500001
DOI: 10.2217/epi-2019-0333
 Art des Abschluß: -

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Titel: EPIGENOMICS
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND : FUTURE MEDICINE LTD
Seiten: - Band / Heft: 12 (21) Artikelnummer: - Start- / Endseite: 1861 - 1870 Identifikator: ISSN: 1750-1911