English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Schema therapy versus cognitive behavioral therapy versus individual supportive therapy for depression in an inpatient and day clinic setting: study protocol of the OPTIMA-RCT

Kopf-Beck, J., Zimmermann, P., Egli, S., Rein, M., Kappelmann, N., Fietz, J., et al. (2020). Schema therapy versus cognitive behavioral therapy versus individual supportive therapy for depression in an inpatient and day clinic setting: study protocol of the OPTIMA-RCT. BMC PSYCHIATRY, 20(1): 506. doi:10.1186/s12888-020-02880-x.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Kopf-Beck, Johannes1, Author           
Zimmermann, Petra2, Author           
Egli, Samy2, Author           
Rein, Martin2, Author           
Kappelmann, Nils1, Author           
Fietz, Julia1, 3, Author           
Tamm, Jeanette1, Author           
Rek, Katharina2, Author           
Lucae, Susanne2, Author           
Brem, Anna-Katherine2, Author           
Saemann, Philipp1, Author           
Schilbach, Leonhard4, Author           
Keck, Martin E.2, Author           
Affiliations:
1Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
3IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, Kraepelinstr. 2-10, 80804 Munich, DE, ou_3318616              
4Independent Max Planck Research Group Social Neuroscience, Max Planck Institute of Psychiatry, Max Planck Society, ou_2253638              

Content

show
hide
Free keywords: BORDERLINE PERSONALITY-DISORDER; RANDOMIZED CONTROLLED-TRIAL; EARLY MALADAPTIVE SCHEMAS; HEART-RATE-VARIABILITY; GERMAN VERSION; ANXIETY DISORDERS; ANTIDEPRESSANT RESPONSE; PSYCHOMETRIC PROPERTIES; MAJOR DEPRESSION; NEGATIVE AFFECTPsychiatry; Depression; Randomized controlled trial; Psychotherapy; Schema therapy; Cognitive behavioral therapy; Supportive therapy; Treatment prediction; Relapse prevention; Mechanisms of change; Personalized psychiatry;
 Abstract: Background: Major depressive disorder represents (MDD) a major cause of disability and disease burden. Beside antidepressant medication, psychotherapy is a key approach of treatment. Schema therapy has been shown to be effective in the treatment of psychiatric disorders, especially personality disorders, in a variety of settings and patient groups. Nevertheless, there is no evidence on its effectiveness for MDD in an inpatient nor day clinic setting and little is known about the factors that drive treatment response in such a target group. Methods: In the current protocol, we outline OPTIMA (OPtimized Treatment Identification at the MAx Planck Institute): a single-center randomized controlled trial of schema therapy as a treatment approach for MDD in an inpatient and day clinic setting. Over the course of 7 weeks, we compare schema therapy with cognitive behavioral therapy and individual supportive therapy, conducted in individual and group sessions and with no restrictions regarding concurrent antidepressant medication, thus approximating real-life treatment conditions.N = 300 depressed patients are included. All study therapists undergo a specific training and supervision and therapy adherence is assessed. Primary outcome is depressive symptom severity as self-assessment (Beck Depression Inventory-II) and secondary outcomes are clinical ratings of MDD (Montgomery-Asberg Depression Rating Scale), recovery rates after 7 weeks according to the Munich-Composite International Diagnostic Interview, general psychopathology (Brief Symptom Inventory), global functioning (World Health Organization Disability Assessment Schedule), and clinical parameters such as dropout rates. Further parameters on a behavioral, cognitive, psychophysiological, and biological level are measured before, during and after treatment and in 2 follow-up assessments after 6 and 24 months after end of treatment. Discussion: To our knowledge, the OPTIMA-Trial is the first to investigate the effectiveness of schema therapy as a treatment approach of MDD, to investigate mechanisms of change, and explore predictors of treatment response in an inpatient and day clinic setting by using such a wide range of parameters. Insights from OPTIMA will allow more integrative approaches of psychotherapy of MDD. Especially, the identification of intervention-specific markers of treatment response can improve evidence-based clinical decision for individualizing treatment.

Details

show
hide
Language(s): eng - English
 Dates: 2020
 Publication Status: Published online
 Pages: 19
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: BMC PSYCHIATRY
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND : BMC
Pages: - Volume / Issue: 20 (1) Sequence Number: 506 Start / End Page: - Identifier: -