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  No robust differences in fear conditioning between patients with fear-related disorders and healthy controls

Pöhlchen, D., Leuchs, L., Binder, F. P., Blaskovich, B., Nantawisarakul, T., Topalidis, P., et al. (2020). No robust differences in fear conditioning between patients with fear-related disorders and healthy controls. BEHAVIOUR RESEARCH AND THERAPY, 129: 103610. doi:10.1016/j.brat.2020.103610.

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Pöhlchen, Dorothee1, 2, Author           
Leuchs, Laura1, Author           
Binder, Florian P.1, 2, Author           
Blaskovich, Borbala1, Author           
Nantawisarakul, Taechawidd1, Author           
Topalidis, Pavlos1, Author
Brückl, Tanja M.1, Author           
Norrholm, Seth D., Author
Jovanovic, Tanja, Author
Spoormaker, Victor I.1, Author           
Binder, Elisabeth B.1, Author           
Czisch, Michael1, Author           
Erhardt, Angelika1, Author           
Grandi, Norma C.3, Author           
Ilic-Cocic, Sanja3, Author           
Lucae, Susanne3, Author           
Saemann, Philipp1, Author           
Tontsch, Alina3, Author           
Affiliations:
1Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              
2IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, Kraepelinstr. 2-10, 80804 Munich, DE, ou_3318616              
3Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: POSTTRAUMATIC-STRESS-DISORDER; EXTINCTION; ANXIETY; STARTLE; PTSD; NEUROSCIENCE; RENEWAL; RETURN; REINSTATEMENT; MAINTENANCEPsychology; Fear conditioning; Fear extinction; Fear recall; Fear-related disorders; PTSD; Panic disorder; Phobia;
 Abstract: Fear conditioning and extinction serve as a dominant model for the development and maintenance of pathological anxiety, particularly for phasic fear to specific stimuli or situations. The validity of this model would be supported by differences in the physiological or subjective fear response between patients with fear-related disorders and healthy controls, whereas the model's validity would be questioned by a lack of such differences. We derived pupillometry, skin conductance response and startle electromyography as well as unconditioned stimulus expectancy in a two-day fear acquisition, immediate extinction and recall task and compared an unmedicated group of patients (n = 73) with phobias or panic disorder and a group of patients with posttraumatic stress disorder (PTSD, n = 21) to a group of carefully screened healthy controls (n = 35). Bayesian statistics showed no convincing evidence for a difference in physiological and subjective responses between the groups during fear acquisition, extinction learning or recall. Only the PTSD subgroup had altered startle reactions during extinction learning. Our data do not provide evidence for general differences in associative fear or extinction learning in fear-related pathologies and thereby question the diagnostic validity of the associative fear learning model of these disorders.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published online
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
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Title: BEHAVIOUR RESEARCH AND THERAPY
Source Genre: Journal
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Publ. Info: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND : PERGAMON-ELSEVIER SCIENCE LTD
Pages: - Volume / Issue: 129 Sequence Number: 103610 Start / End Page: - Identifier: ISSN: 0005-7967