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Free keywords:
OXIDATIVE STRESS; LIPID-PEROXIDATION; RISK; F-2-ISOPROSTANES;
8-ISOPROSTANE; ISOPROSTANES; INFLAMMATION; DIAGNOSIS; BIOMARKER; PLASMANeurosciences & Neurology; 8-iso-prostaglandin F-2 alpha; Alzheimer's disease; cohort study;
dementia; oxidative stress; vascular dementia;
Abstract:
Introduction: Prospective studies on a potential association of 8-iso-prostaglandin F-2 alpha (8-iso-PGF(2 alpha)) levels, a biomarker of lipid peroxidation, with dementia are limited.
Methods: Multivariate Cox regression models were used to assess potential associations of urinary 8-iso-PGF(2 alpha) levels with all-cause, Alzheimer's disease (AD), and vascular dementia (VD) incidence in 5853 older adults from a German, population-based cohort.
Results: Over 14 years of follow-up, 365 all-cause dementia cases including 127 VD and 109 AD cases were diagnosed. Participants in the top compared to the bottom 8-iso-PGF(2 alpha) tertile had a 45% increased risk of all-cause dementia incidence (hazard ratio [95% confidence interval]: 1.45 [1.12 to 1.88]). Interaction with the apolipoprotein E (APOE) epsilon 4/epsilon 4 genotype was detected (P = .02). Furthermore, continuously modeled, log-arithmized 8-iso-PGF(2 alpha), levels were statistically significantly associated with all-cause dementia and AD incidence.
Discussion: Oxidative stress may be involved in the pathogenesis of dementia. Individuals with increased 8-iso-PGF(2 alpha), levels and the APOE epsilon 4/epsilon 4 genotype showed a considerably increased dementia risk.
