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  The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder

Comes, A. L., Czamara, D., Adorjan, K., Anderson-Schmidt, H., Andlauer, T. F. M., Budde, M., et al. (2020). The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder. INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS, 8(1): 9. doi:10.1186/s40345-019-0176-6.

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 Creators:
Comes, Ashley L.1, Author           
Czamara, Darina2, Author           
Adorjan, Kristina, Author
Anderson-Schmidt, Heike, Author
Andlauer, Till F. M.2, Author           
Budde, Monika, Author
Gade, Katrin, Author
Hake, Maria, Author
Kalman, Janos L.1, Author           
Papiol, Sergi, Author
Reich-Erkelenz, Daniela, Author
Kloehn-Saghatolislam, Farah, Author
Schaupp, Sabrina K., Author
Schulte, Eva C., Author
Senner, Fanny, Author
Juckel, Georg, Author
Schmauss, Max, Author
Zimmermann, Joerg, Author
Reimer, Jens, Author
Reininghaus, Eva, Author
Anghelescu, Ion-George, AuthorKonrad, Carsten, AuthorThiel, Andreas, AuthorFigge, Christian, Authorvon Hagen, Martin, AuthorKoller, Manfred, AuthorDietrich, Detlef E., AuthorStierl, Sebastian, AuthorScherk, Harald, AuthorWitt, Stephanie H., AuthorSivalingam, Sugirthan, AuthorDegenhardt, Franziska, AuthorForstner, Andreas J., AuthorRietschel, Marcella, AuthorNoethen, Markus M., AuthorWiltfang, Jens, AuthorFalkai, Peter, AuthorSchulze, Thomas G., AuthorHeilbronner, Urs, Author more..
Affiliations:
1IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_3318616              
2Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              

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Free keywords: GENOME-WIDE ASSOCIATION; CHILDHOOD TRAUMA; LIFE EVENTS; MOOD DISORDERS; RISK; SCALE; VALIDATION; DISCOVERY; EPIGENOME; VALIDITYPsychiatry; DNA methylation; Bipolar disorder; Stressful life events; Longitudinal; Epigenomics; Epigenetic aging;
 Abstract: Background Stressful life events influence the course of affective disorders, however, the mechanisms by which they bring about phenotypic change are not entirely known. Methods We explored the role of DNA methylation in response to recent stressful life events in a cohort of bipolar patients from the longitudinal PsyCourse study (n = 96). Peripheral blood DNA methylomes were profiled at two time points for over 850,000 methylation sites. The association between impact ratings of stressful life events and DNA methylation was assessed, first by interrogating methylation sites in the vicinity of candidate genes previously implicated in the stress response and, second, by conducting an exploratory epigenome-wide association analysis. Third, the association between epigenetic aging and change in stress and symptom measures over time was investigated. Results Investigation of methylation signatures over time revealed just over half of the CpG sites tested had an absolute difference in methylation of at least 1% over a 1-year period. Although not a single CpG site withstood correction for multiple testing, methylation at one site (cg15212455) was suggestively associated with stressful life events (p < 1.0 x 10(-5)). Epigenetic aging over a 1-year period was not associated with changes in stress or symptom measures. Conclusions To the best of our knowledge, our study is the first to investigate epigenome-wide methylation across time in bipolar patients and in relation to recent, non-traumatic stressful life events. Limited and inconclusive evidence warrants future longitudinal investigations in larger samples of well-characterized bipolar patients to give a complete picture regarding the role of DNA methylation in the course of bipolar disorder.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published online
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000512780000001
DOI: 10.1186/s40345-019-0176-6
 Degree: -

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Title: INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
Source Genre: Journal
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Publ. Info: ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES : SPRINGER
Pages: - Volume / Issue: 8 (1) Sequence Number: 9 Start / End Page: - Identifier: ISSN: 2194-7511