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  Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus

Leidmaa, E., Gazea, M., Patchev, A. V., Pissioti, A., Gassen, N. C., Kimura, M., et al. (2020). Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus. ACTA PHYSIOLOGICA, 228(2): e13345. doi:10.1111/apha.13345.

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Leidmaa, Este1, Autor           
Gazea, Mary1, Autor           
Patchev, Alexandre V.2, Autor           
Pissioti, Anna1, Autor           
Gassen, Nils Christian3, Autor           
Kimura, Mayumi1, Autor           
Liposits, Zsolt, Autor
Kallo, Imre, Autor
Almeida, Osborne F. X.1, Autor           
Affiliations:
1Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035294              
2Max Planck Institute of Psychiatry, Max Planck Society, Kraepelinstr. 2-10, 80804 Munich, DE, ou_1607137              
3Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              

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Schlagwörter: VENTRAL TEGMENTAL AREA; MESOLIMBIC DOPAMINE SYSTEM; FOOD-INTAKE; OREXIN NEURONS; NEUROTENSIN NEURONS; PERIPHERAL GHRELIN; NEUROPEPTIDE-Y; BODY-WEIGHT; REWARD; RESISTANCEPhysiology; galanin; ghrelin; lateral hypothalamus; leptin; orexin; overeating;
 Zusammenfassung: Aim Since foods with high hedonic value are often consumed in excess of energetic needs, this study was designed to identify the mechanisms that may counter anorexigenic signalling in the presence of hedonic foods in lean animals. Methods Mice, in different states of satiety (fed/fasted, or fed/fasted and treated with ghrelin or leptin, respectively), were allowed to choose between high-fat/high-sucrose and standard foods. Intake of each food type and the activity of hypothalamic neuropetidergic neurons that regulate appetite were monitored. In some cases, food choice was monitored in leptin-injected fasted mice that received microinjections of galanin receptor agonists into the lateral hypothalamus. Results Appetite-stimulating orexin neurons in the lateral hypothalamus are rapidly activated when lean, satiated mice consume a highly palatable food (PF); such activation (upregulated c-Fos expression) occurred even after administration of the anorexigenic hormone leptin and despite intact leptin signalling in the hypothalamus. The ability of leptin to restrain PF eating is restored when a galanin receptor 2 (Gal2R) agonist is injected into the lateral hypothalamus. Conclusion Hedonically-loaded foods interrupt the inhibitory actions of leptin on orexin neurons and interfere with the homeostatic control of feeding. Overeating of palatable foods can be curtailed in lean animals by activating Gal2R in the lateral hypothalamus.

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Sprache(n): eng - English
 Datum: 2019-07-312020-02
 Publikationsstatus: Erschienen
 Seiten: 16
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000479675900001
DOI: 10.1111/apha.13345
 Art des Abschluß: -

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Titel: ACTA PHYSIOLOGICA
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: 111 RIVER ST, HOBOKEN 07030-5774, NJ USA : WILEY
Seiten: - Band / Heft: 228 (2) Artikelnummer: e13345 Start- / Endseite: - Identifikator: ISSN: 1748-1708