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  Deciphering the assembly pathway of Sm‐class U snRNPs

Neuenkirchen, N., Chari, A., & Fischer, U. (2008). Deciphering the assembly pathway of Sm‐class U snRNPs. FEBS Letters, 582(14), 1997-2003. doi:10.1016/j.febslet.2008.03.009.

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3288834.pdf (Publisher version), 624KB
 
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Neuenkirchen, N., Author
Chari, A.1, Author           
Fischer, U., Author
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1Research Group of Structural Biochemistry and Mechanisms, MPI for Biophysical Chemistry, Max Planck Society, ou_3265855              

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Free keywords: snRNA, small nuclear RNA, snRNP, small nuclear ribonucleoprotein, SMN, survival motor neuron, PRMT5, p protein arginine methyltransferase 5, WD45, WD repeat domain 45, pICln, chloride conductance regulatory protein, CBC, cap-binding complex, PHAX, phosphorylated adaptor for RNA export, CRM1, chromosome region maintenance 1, RanGTP, Ras-related nuclear protein bound to GTP, NPC, nuclear pore complex, Tgs1, trimethylguanosine synthetase1, NLS, nuclear localization signal, SPN1, snurportin-1, Lsm proteins, like Sm protein, U snRNP biogenesis, SMN-complex, PRMT5-complex, Sm proteins, Splicing, U snRNA
 Abstract: The assembly of the Sm‐class of uridine‐rich small nuclear ribonucleoproteins (U snRNPs), albeit spontaneous in vitro, has recently been shown to be dependent on the aid of a large number of assisting factors in vivo. These factors are organized in two interacting units termed survival motor neuron (SMN)‐ and protein arginine methyltransferase 5 (PRMT5)‐complexes, respectively. While the PRMT5‐complex acts early in the assembly pathway by activating common proteins of U snRNPs, the SMN‐complex functions to join proteins and RNA in a highly ordered, apparently regulated manner. Here, we summarize recent progress in the understanding of this process and discuss the influence exerted by the aforementioned trans‐acting factors.

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Language(s): eng - English
 Dates: 2008-03-172008-06-14
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.febslet.2008.03.009
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Title: FEBS Letters
Source Genre: Journal
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Pages: - Volume / Issue: 582 (14) Sequence Number: - Start / End Page: 1997 - 2003 Identifier: -