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  Revisiting the global workspace orchestrating the hierarchical organization of the human brain

Deco, G., Vidaurre, D., & Kringelbach, M. L. (2021). Revisiting the global workspace orchestrating the hierarchical organization of the human brain. Nature Human Behaviour, 5(4), 497-511. doi:10.1038/s41562-020-01003-6.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0008-104C-1 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-F250-7
Genre: Journal Article

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 Creators:
Deco, Gustavo1, 2, 3, 4, Author           
Vidaurre, Diego5, 6, Author
Kringelbach, Morten L.5, 7, 8, Author
Affiliations:
1Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
4School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
5Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
6Center of Functionally Integrative Neuroscience, Aarhus University, Denmark, ou_persistent22              
7Centre for Eudaimonia and Human Flourishing, University of Oxford, United Kingdom, ou_persistent22              
8Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              

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Free keywords: Cognitive control; Neuroscience; Psychology
 Abstract: A central challenge in neuroscience is how the brain organizes the information necessary to orchestrate behaviour. Arguably, this whole-brain orchestration is carried out by a core subset of integrative brain regions, a 'global workspace', but its constitutive regions remain unclear. We quantified the global workspace as the common regions across seven tasks as well as rest, in a common 'functional rich club'. To identify this functional rich club, we determined the information flow between brain regions by means of a normalized directed transfer entropy framework applied to multimodal neuroimaging data from 1,003 healthy participants and validated in participants with retest data. This revealed a set of regions orchestrating information from perceptual, long-term memory, evaluative and attentional systems. We confirmed the causal significance and robustness of our results by systematically lesioning a generative whole-brain model. Overall, this framework describes a complex choreography of the functional hierarchical organization of the human brain.

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Language(s): eng - English
 Dates: 2020-03-182020-10-122021-01-042021-04
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41562-020-01003-6
Other: epub 2021
PMID: 33398141
 Degree: -

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Project name : -
Grant ID : 945539
Funding program : Human Brain Project
Funding organization : European Union
Project name : -
Grant ID : 615539
Funding program : -
Funding organization : European Research Council (ERC)
Project name : -
Grant ID : PID2019-105772GB-I00 AEI FEDER EU
Funding program : -
Funding organization : Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI) and European Regional Development Funds (FEDER)
Project name : SGR Research Support Group
Grant ID : 2017 SGR 1545
Funding program : -
Funding organization : Catalan Agency for Management of University and Research Grants (AGAUR)
Project name : -
Grant ID : DNRF117
Funding program : -
Funding organization : Danish National Research Foundation (DNRF)

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Title: Nature Human Behaviour
Source Genre: Journal
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Publ. Info: London : Nature Research
Pages: - Volume / Issue: 5 (4) Sequence Number: - Start / End Page: 497 - 511 Identifier: ISSN: 2397-3374
CoNE: https://pure.mpg.de/cone/journals/resource/2397-3374