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  Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years

Dima, D., Modabbernia, A., Papachristou, E., Doucet, G. E., Agartz, I., Aghajani, M., et al. (2022). Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years. Human Brain Mapping, 43(1), 452-469. doi:10.1002/hbm.25320.

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© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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 Creators:
Dima, Danai1, 2, Author
Modabbernia, Amirhossein3, Author
Papachristou, Efstathios4, Author
Doucet, Gaelle E.5, Author
Agartz, Ingrid6, 7, 8, Author
Aghajani, Moji9, 10, Author
Akudjedu, Theophilus N.11, 12, Author
Albajes‐Eizagirre, Anton13, 14, Author
Alnæs, Dag6, Author
Alpert, Kathryn I.15, Author
Andersson, Micael16, Author
Andreasen, Nancy C.17, Author
Andreassen, Ole A.6, Author
Asherson, Philip2, Author
Banaschewski, Tobias18, Author
Bargallo, Nuria19, 20, Author
Baumeister, Sarah18, Author
Baur‐Streubel, Ramona21, Author
Bertolino, Alessandro22, Author
Bonvino, Aurora22, Author
Boomsma, Dorret I.23, AuthorBorgwardt, Stefan24, AuthorBourque, Josiane25, AuthorBrandeis, Daniel18, AuthorBreier, Alan26, AuthorBrodaty, Henry27, AuthorBrouwer, Rachel M.28, AuthorBuitelaar, Jan K.29, 30, 31, AuthorBusatto, Geraldo F.32, AuthorBuckner, Randy L.33, 34, AuthorCalhoun, Vincent35, AuthorCanales‐Rodríguez, Erick J.13, 14, AuthorCannon, Dara M.12, AuthorCaseras, Xavier36, AuthorCastellanos, Francisco X.37, AuthorCervenka, Simon8, 38, AuthorChaim‐Avancini, Tiffany M.32, AuthorChing, Christopher R. K.39, AuthorChubar, Victoria40, AuthorClark, Vincent P.41, 42, AuthorConrod, Patricia43, AuthorConzelmann, Annette44, AuthorCrespo‐Facorro, Benedicto14, 45, AuthorCrivello, Fabrice46, AuthorCrone, Eveline A.10, 47, AuthorDale, Anders M.48, AuthorDavey, Christopher49, AuthorDe Geus, Eco J. C.23, AuthorDe Haan, Lieuwe50, AuthorDe Zubicaray, Greig I.51, AuthorDen Braber, Anouk23, AuthorDickie, Erin W.52, 53, AuthorDi Giorgio, Annabella 54, AuthorDoan, Nhat Trung6, AuthorDørum, Erlend S.6, 55, AuthorEhrlich, Stefan56, AuthorErk, Susanne57, AuthorEspeseth, Thomas6, 58, AuthorFatouros‐Bergman, Helena8, 38, AuthorFisher, Simon E.29, 59, Author           Fouche, Jean‐Paul60, AuthorFranke, Barbara29, 61, AuthorFrodl, Thomas62, AuthorFuentes‐Claramonte, Paola13, 14, AuthorGlahn, David C.63, AuthorGotlib, Ian H.64, AuthorGrabe, Hans‐Jörgen65, 66, AuthorGrimm, Oliver67, AuthorGroenewold, Nynke A.60, AuthorGrotegerd, Dominik68, AuthorGruber, Oliver18, AuthorGruner, Patricia69, 70, AuthorGur, Rachel E.25, AuthorGur, Ruben C.25, AuthorHarrison, Ben J.49, AuthorHartman, Catharine A.71, AuthorHatton, Sean N.72, AuthorHeinz, Andreas57, AuthorHeslenfeld, Dirk J.23, AuthorHibar, Derrek P.73, AuthorHickie, Ian B.72, AuthorHo, Beng‐Choon6, AuthorHoekstra, Pieter J.71, AuthorHohmann, Sarah18, AuthorHolmes, Avram J.69, AuthorHoogman, Martine29, 61, AuthorHosten, Norbert74, AuthorHowells, Fleur M.60, AuthorHulshoff Pol, Hilleke E. 28, AuthorHuyser, Chaim75, AuthorJahanshad, Neda39, AuthorJames, Anthony76, AuthorJernigan, Terry L.48, AuthorJiang, Jiyang27, AuthorJönsson, Erik G.8, 38, AuthorJoska, John A.60, AuthorKahn, Rene3, AuthorKalnin, Andrew77, AuthorKanai, Ryota78, AuthorKlein, Marieke29, 48, 61, AuthorKlyushnik, Tatyana P.79, AuthorKoenders, Laura50, AuthorKoops, Sanne28, AuthorKrämer, Bernd18, AuthorKuntsi, Jonna2, AuthorLagopoulos, Jim80, AuthorLázaro, Luisa14, 19, AuthorLebedeva, Irina79, AuthorLee, Won Hee3, AuthorLesch, Klaus‐Peter21, AuthorLochner, Christine81, AuthorMachielsen, Marise W. J.50, AuthorMaingault, Sophie46, AuthorMartin, Nicholas G.82, AuthorMartínez‐Zalacaín, Ignacio14, 83, AuthorMataix‐Cols, David8, 38, AuthorMazoyer, Bernard46, AuthorMcDonald, Colm12, AuthorMcDonald, Brenna C.26, AuthorMcIntosh, Andrew M.84, AuthorMcMahon, Katie L.51, AuthorMcPhilemy, Genevieve12, AuthorMenchón, José M.14, 83, AuthorMedland, Sarah E.82, AuthorMeyer‐Lindenberg, Andreas18, AuthorNaaijen, Jilly30, 31, AuthorNajt, Pablo12, AuthorNakao, Tomohiro85, AuthorNordvik, Jan E.86, AuthorNyberg, Lars16, AuthorOosterlaan, Jaap9, AuthorOrtiz‐García de la Foz, Víctor 14, 87, 88, AuthorPaloyelis, Yannis2, AuthorPauli, Paul21, AuthorPergola, Giulio22, AuthorPomarol‐Clotet, Edith13, 14, AuthorPortella, Maria J.13, 89, AuthorPotkin, Steven G.90, AuthorRadua, Joaquim2, 8, 20, AuthorReif, Andreas67, AuthorRinker, Daniel A.6, AuthorRoffman, Joshua L.34, AuthorRosa, Pedro G. P.32, AuthorSacchet, Matthew D.63, AuthorSachdev, Perminder S.27, AuthorSalvador, Raymond13, AuthorSánchez‐Juan, Pascual87, 91, AuthorSarró, Salvador13, AuthorSatterthwaite, Theodore D.25, AuthorSaykin, Andrew J.26, AuthorSerpa, Mauricio H.32, AuthorSchmaal, Lianne49, 92, AuthorSchnell, Knut93, AuthorSchumann, Gunter2, AuthorSim, Kang94, AuthorSmoller, Jordan W.34, AuthorSommer, Iris71, AuthorSoriano‐Mas, Carles14, 83, AuthorStein, Dan J.81, AuthorStrike, Lachlan T.95, AuthorSwagerman, Suzanne C.23, AuthorTamnes, Christian K.6, 7, AuthorTemmingh, Henk S.60, AuthorThomopoulos, Sophia I.39, AuthorTomyshev, Alexander S.79, AuthorTordesillas‐Gutiérrez, Diana13, 87, AuthorTrollor, Julian N.27, AuthorTurner, Jessica A.96, AuthorUhlmann, Anne60, AuthorVan den Heuvel, Odile A.9, AuthorVan den Meer, Dennis6, 97, AuthorVan der Wee, Nic J. A.98, 99, AuthorVan Haren, Neeltje E. M.100, AuthorVan't Ent, Dennis 23, AuthorVan Erp, Theo G. M.65, 90, AuthorVeer, Ilya M.57, AuthorVeltman, Dick J.9, AuthorVoineskos, Aristotle52, 53, AuthorVölzke, Henry65, 101, 102, AuthorWalter, Henrik57, AuthorWalton, Esther103, AuthorWang, Lei104, AuthorWang, Yang105, AuthorWassink, Thomas H.17, AuthorWeber, Bernd106, AuthorWen, Wei27, AuthorWest, John D.26, AuthorWestlye, Lars T.6, AuthorWhalley, Heather84, AuthorWierenga, Lara M.10, AuthorWilliams, Steven C. R.2, AuthorWittfeld, Katharina65, 66, AuthorWolf, Daniel H.25, AuthorWorker, Amanda2, AuthorWright, Margaret J.95, AuthorYang, Kun107, AuthorYoncheva, Yulyia37, AuthorZanetti, Marcus V.32, 108, AuthorZiegler, Georg C.21, AuthorThompson, Paul M.39, AuthorFrangou, Sophia3, 109, AuthorKarolinska Schizophrenia Project (KaSP), Author               more..
Affiliations:
1City University of London, London, UK, ou_persistent22              
2King's College London , London, UK, ou_persistent22              
3Icahn School of Medicine at Mount Sinai, New York, NY, USA, ou_persistent22              
4University College London, London, UK, ou_persistent22              
5Boys Town National Research Hospital , Omaha, NE, USA, ou_persistent22              
6University of Oslo, Oslo, Norway, ou_persistent22              
7Diakonhjemmet Hospital, Oslo, Norway, ou_persistent22              
8Karolinska Institutet, Stockholm, Sweden, ou_persistent22              
9Amsterdam University Medical Centre, Location VUmc, Amsterdam, The Netherlands, ou_persistent22              
10Leiden University, Leiden, The Netherlands, ou_persistent22              
11Bournemouth University, Poole, UK, ou_persistent22              
12National University of Ireland, Dublin, Ireland, ou_persistent22              
13FIDMAG Germanes Hospitalàries, Madrid, Spain, ou_persistent22              
14Mental Health Research Networking Center (CIBERSAM), Madrid, Spain, ou_persistent22              
15Radiologics, Inc., Chicago, IL, USA, ou_persistent22              
16Umeå University, Umeå, Sweden, ou_persistent22              
17University of Iowa , Iowa City, IA, USA, ou_persistent22              
18Heidelberg University, Mannheim, Germany, ou_persistent22              
19Barcelona University Clinic, Barcelona, Spain, ou_persistent22              
20August Pi i Sunyer Biomedical Research Institut (IDIBAPS), Barcelona, Spain, ou_persistent22              
21University of Würzburg, Würzburg, Germany, ou_persistent22              
22University of Bari Aldo Moro, Bari, Italy, ou_persistent22              
23Vrije Universiteit Amsterdam, Amsterdam, The Netherlands, ou_persistent22              
24University of Lübeck, Lübeck, Germany, ou_persistent22              
25University of Pennsylvania, Philadelphia, PA, USA, ou_persistent22              
26Indiana University School of Medicine, Indianapolis, IN, USA, ou_persistent22              
27University of New South Wales, Sydney, Australia, ou_persistent22              
28University Medical Center Utrecht, Utrecht, The Netherlands, ou_persistent22              
29Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
30FC Donders Centre for Cognitive Neuroimaging , External Organizations, ou_55235              
31Radboud University Nijmegen, External Organizations, ou_3055479              
32Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ou_persistent22              
33Harvard University, Cambridge, MA, USA, ou_persistent22              
34Massachusetts General Hospital, Boston, MA, USA, ou_persistent22              
35Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Atlanta, GA, USA, ou_persistent22              
36Cardiff University, Cardiff, UK, ou_persistent22              
37New York University, New York, NY, USA, ou_persistent22              
38Stockholm Health Care Services, Stockholm, Sweden, ou_persistent22              
39Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, ou_persistent22              
40KU Leuven, Leuven, Belgium, ou_persistent22              
41University of New Mexico, Albuquerque, NM, USA, ou_persistent22              
42Mind Research Network, Albuquerque, NM, USA, ou_persistent22              
43Université de Montréal, Montreal, Canada, ou_persistent22              
44University of Tübingen, Tubingen, Germany, ou_persistent22              
45University of Sevilla, Sevilla, Spain, ou_persistent22              
46Université de Bordeaux , Talence, France, ou_persistent22              
47Erasmus University Rotterdam, Rotterdam, The Netherlands, ou_persistent22              
48University of California, San Diego , La Jolla, CA, USA, ou_persistent22              
49University of Melbourne, Melbourne, Australia, ou_persistent22              
50Amsterdam University Medical Centre, Location UvA, Amsterdam, The Netherlands, ou_persistent22              
51Queensland University of Technology, Brisbane, Australia, ou_persistent22              
52Campbell Family Mental Health Research Institute, Toronto, Canada, ou_persistent22              
53University of Toronto, Toronto, Canada, ou_persistent22              
54Fondazione IRCCS Casa Sollievo della Sofferenza , San Giovanni Rotondo, Italy, ou_persistent22              
55Sunnaas Rehabilitation Hospital HT, Nesodden, Norway, ou_persistent22              
56Technische Universität Dresden, Dresde, Germany, ou_persistent22              
57Charité-Universitätsmedizin Berlin, Berlin, Germany, ou_persistent22              
58Bjørknes College, Oslo, Norway, ou_persistent22              
59Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
60University of Cape Town, Rondebosch, South Africa, ou_persistent22              
61Radboud University Medical Center, Nijmegen, The Netherlands, ou_persistent22              
62Otto von Guericke University Magdeburg, Magdeburg, Germany, ou_persistent22              
63Harvard Medical School, Boston, MA, USA, ou_persistent22              
64Stanford University, Stanford, CA, USA, ou_persistent22              
65University of Greifswald, Greifswald, Germany, ou_persistent22              
66German Center for Neurodegenerative Diseases (DZNE), Greifswald, Germany, ou_persistent22              
67Universitätsklinikum Frankfurt, Goethe Universitat, Frankfurt, Germany, ou_persistent22              
68University of Münster, Munster, Germany, ou_persistent22              
69Yale University, New Haven, CT, USA, ou_persistent22              
70VA Connecticut Health System, New Haven, CT, USA, ou_persistent22              
71University Medical Center Groningen, Groningen, The Netherlands, ou_persistent22              
72University of Sydney, Sydney, Australia, ou_persistent22              
73Genentech, Inc., South San Francisco, CA, USA, ou_persistent22              
74University Medicine Greifswald, University of Greifswald, Greifswald, Germany, ou_persistent22              
75Bascule, Academic Centre for Children and Adolescent Psychiatry, Duivendrecht, The Netherlands, ou_persistent22              
76Oxford University, Oxford, UK, ou_persistent22              
77Ohio State University College of Medicine, Columbus, OH, USA, ou_persistent22              
78Araya, Inc., Tokyo, Japan, ou_persistent22              
79Russian Academy of Medical Sciences, Moskva, Russia, ou_persistent22              
80University of the Sunshine Coast, Sunshine Coast, Australia, ou_persistent22              
81Stellenbosch University, Stellenbosch, South Africa, ou_persistent22              
82Queensland Institute of Medical Research, Berghofer Medical Research Institute, Brisbane, Australia, ou_persistent22              
83Bellvitge University Hospital-IDIBELL, Barcelona, Spain, ou_persistent22              
84University of Edinburgh, Edinburgh, UK, ou_persistent22              
85Kyushu University, Kyushu, Japan, ou_persistent22              
86CatoSenteret Rehabilitation Hospital, Son, Norway, ou_persistent22              
87Instituto de Investigación Valdecilla (IDIVAL), Santander, Spain, ou_persistent22              
88Instituto de Salud Carlos III, Madrid, Spain, ou_persistent22              
89Universitat Autònoma de Barcelona, Barcelona, Spain, ou_persistent22              
90University of California at Irvine, Irvine, CA, USA, ou_persistent22              
91Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain, ou_persistent22              
92Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia, ou_persistent22              
93University Medical Center Göttingen, Göttingen, Germany, ou_persistent22              
94Institute of Mental Health, Singapore, Singapore, ou_persistent22              
95University of Queensland, Brisbane, Australia, ou_persistent22              
96Georgia State University, Atlanta, GA, USA, ou_persistent22              
97Maastricht University, Maastricht, The Netherlands, ou_persistent22              
98Leiden University Medical Center, Leiden, The Netherlands, ou_persistent22              
99Leiden Institute for Brain and Cognition, Leiden, The Netherlands, ou_persistent22              
100Erasmus University Medical Center, Rotterdam, The Netherlands, ou_persistent22              
101German Centre for Cardiovascular Research (DZHK), Greifswald, Germany, ou_persistent22              
102German Center for Diabetes Research (DZD), Greifswald, Germany, ou_persistent22              
103University of Bath, Bath, UK, ou_persistent22              
104Feinberg School of Medicine, Northwestern University, Chicago, IL, USA, ou_persistent22              
105Medical College of Wisconsin , Milwaukee, WI, USA, ou_persistent22              
106University of Bonn, Bonn, Germany, ou_persistent22              
107Florida State University , Tallahassee, FL, USA, ou_persistent22              
108Hospital Sírio-Libanês, São Paulo, Brazil, ou_persistent22              
109University of British Columbia, Vancouver, Canada, ou_persistent22              

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 Abstract: Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta‐Analysis (ENIGMA) Consortium to examine age‐related trajectories inferred from cross‐sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3–90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter‐individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age‐related morphometric patterns.

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Language(s): eng - English
 Dates: 2021-02-112022-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/hbm.25320
 Degree: -

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 43 (1) Sequence Number: - Start / End Page: 452 - 469 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686