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  Effect of cyclic nucleotides on the isotonic fluid reabsorption in the proximal convoluted tubule of rat kidney

Baumann, K., Bode, F., & Papavassiliou, F. (1976). Effect of cyclic nucleotides on the isotonic fluid reabsorption in the proximal convoluted tubule of rat kidney. Current problems in clinical biochemistry, 6, 123-133.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0008-1302-0 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0008-CBF3-1
Genre: Zeitschriftenartikel

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 Urheber:
Baumann, Karl1, Autor           
Bode, Folkert1, Autor           
Papavassiliou, Friderun1, Autor           
Affiliations:
1Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068297              

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Schlagwörter: -
 Zusammenfassung: In order to reveal the sidedness of the cyclic AMP action on renal tubules the effect of cyclic nucleotides on isotonic fluid reabsorption was examined in proximal convoluted rat kidney tubules by using advanced micropuncture techniques. Cyclic AMP inhibited isotonic fluid reabsorption preferentially when applied on the luminal cell side. This finding coincides with a predominant distribution of a membrane bound cyclic AMP dependent protein kinase in a luminal cell membrane fraction. On the luminal cell side cyclic AMP and dibutyryl cyclic AMP inhibited isotonic fluid reabsorption in a similar dose dependent behaviour. Concentrations of both nucleotides as low as 10-10M had a definite inhibitory effect. Tested at a high concentration N6-butyryl cyclic AMP was almost as effective as cyclic AMP. Deoxy cyclic AMP, 5' AMP, cyclic GMP and dibutyryl cyclic GMP had no effect. ATP inhibited isotonic fluid reabsorption to a very small extent. The data indicate that the observed inhibition of isotonic fluid reabsorption is specific for cyclic AMP and that the interaction of cyclic AMP and the luminal cell membrane is initiated at the luminal cell surface.

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Sprache(n): eng - English
 Datum: 1976-01-01
 Publikationsstatus: Erschienen
 Seiten: 11
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: PMID: 187377
 Art des Abschluß: -

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Titel: Current problems in clinical biochemistry
  Kurztitel : Curr Probl Clin Biochem
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Bern, Switzerland : Hans Huber
Seiten: - Band / Heft: 6 Artikelnummer: - Start- / Endseite: 123 - 133 Identifikator: ISSN: 0300-1725