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  RAC1 controls progressive movement and competitiveness of mammalian spermatozoa

Amaral, A., & Herrmann, B. G. (2021). RAC1 controls progressive movement and competitiveness of mammalian spermatozoa. PLoS Genetics, 17(2): e1009308. doi:10.1371/journal.pgen.1009308.

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Amaral_2021.pdf (Publisher version), 3MB
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© 2021 Amaral, Herrmann

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 Creators:
Amaral, Alexandra1, Author              
Herrmann, Bernhard G.1, Author              
Affiliations:
1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

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 Abstract: Spermatozoa are highly specialized cells designed for one particular purpose: to swim towards the egg cells and fertilize them. Swimming is achieved by propelling rotation of the flagellum, a complex molecular motor. Many proteins building the flagellum have been identified, and mechanisms generating forward movement have been elucidated in some detail. However, how movement is directed towards the egg cells, is not well understood. In this study, we provide evidence that the Rho small GTPase RAC1 plays a pivotal role in sperm progressive movement. We show that inappropriately high or low RAC1 activity impairs progressive movement and the competitiveness of sperm within a sperm population. Sperm with balanced RAC1 activity therefore gain a selective advantage in reaching and fertilizing egg cells, as exemplified by the mouse t-haplotype. Our data highlight the importance of Rho signaling in controlling progressive motility, in sperm competition, non-Mendelian inheritance and male (in)fertility.

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Language(s): eng - English
 Dates: 2020-12-102021-02-04
 Publication Status: Published online
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 Identifiers: DOI: 10.1371/journal.pgen.1009308
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Title: PLoS Genetics
  Other : PLoS Genet.
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 17 (2) Sequence Number: e1009308 Start / End Page: - Identifier: ISSN: 1553-7390
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000017180